Pharm questions Flashcards
What is the order of drug development?
Preclinical—>IDN application—>phase I (figure out the dosage)—>phase II (efficacy)—>phase III—>phase IV
What does preclinical studies consist of for drug development?
Test the drug on cancer cell line/test on animals for efficacy and toxicity
Where do you file IDN application?
FDA
What does the phase I trial establish?
Safety
Can N7 alkylated guaine bind with thymine?
Yes, mutagenic
For phase III trial, which combo is better treating Hodgkin’s lymphoma, ABVD or CHOPP?
ABVD
What does phase IV establish?
Long term safety and effectiveness of the drug
All trans retinoic acid is a metabolite of Vitamin __?
A
For metastatic cancer, which is better, combo or mono drug?
Combo (e.g. FEC for metastatic breast cancer)
Cytarabine is converted by ___ to Ara-CMP?
deoxycytidine kinase
What does MXT inhibit?
DHFR and TS
What does Cytarabine inhibit?
DNA polymerase
What does phase III establish?
If the drug is more effective than current treatment option
What can cause high output cardiac failure?
Anemia
Low bone marrow suppression
Cisplatin
How to calculate Ke?
Cl/Vd
Css = ?
K0/Cl
HA form is lipid soluble or not?
Soluble
When pKa = pH ___ = ___?
the con. of ionized and unionized form drug is equal
Condyloma latum in what stage of syphills?
2nd
Endometriosis increase chance of ?
Carcinoma
What is pseudomyxoma peritonei from?
Mucinous tumor in appendix
What does osteopetrosis has mutation of?
carbonic anhydrase II
