Pharm Pulmonary Exam 2 Flashcards
COPD order of therapy
LAMA
Then
LABA
Then
ICS
Stable COPD
Quick relief of symptoms
for patients already on a LAMA
SABA
Short acting beta agonist
Stable COPD
Group B
GOLD ABCD
Group B is usually hospitalized with steroids
moderate to severe symptoms
Tiotropium
Spiriva (long acting anticholinergic)
For long term maintenance of bronchospasm due to COPD. Includes chronic bronchitis and emphysema.
Reduces exacerbations of COPD
Dose: 2 puffs of one capsule (18mcg) QD
Contra
Allergy to ipratropium
Interactions:
Other anticholinergics
Adverse:
Anti-cholinergic effects, Glaucoma, dysuria, blurred vision, constipation, urinary retention
Symbicort Name
Budesonide - formoterol MDI
Advair HFA Name
Fluticasone propionate - salmeterol MDI
Advair Diskus Name
Fluticasone propionate - salmeterol DPI
Breo Ellipta Name
Fluticasone furoate - vilanterol DPI
Dulera Name
Mometasone - formoterol MDI
Fluticasone propionate - salmeterol MDI
250 mcg / 50mcg
Advair Diskus
(corticosteroid + LABA)
Dose: Asthma:
>12 y/o = 1 puff of 100/50 or 250/50 or 500/50 BID
Children: rinse mouth after use
Contra:
Primary treatment of status asthmaticus or other acute asthma or COPD
Interactions:
Caution during 2 weeks of discontinuing MAOI’s or tricyclics
Adverse:
URI
2 Combo LAMA/LABA’s
Tiotropium 2.5mcg
olodaterol 5.5mcg
(Stiolto Respimat)
Fluticasone furoate 100mcg
umeclidnium 62.5mcg
vilanterol 25mcg
(Trelegy Ellipta)
COPD exacerbation definition
Acute increase in symptoms beyond normal day to day variation that leads to a change in medication
COPD exacerbation treatment
SABA is mainstay of treatment
Short acting beta-adrenergic agonist
(albuterol, Levalbuterol)
All patients with COPD exacerbation should get steroids
ICU dose = prednisone 40-60 PO QD 5-14 days
ABX may be indicated for many patients
COPD exacerbation ABX treatment
No pseudomonas risk factors:
Used for majority of COPD exacerbations
(use pseudomonas risk factors, sputum cultures and patterns of resistance)
No pseudomonas risk factors:
1-2 g Cef IV,
or
levo 500 IV
or
moxi 400 IV
COPD exacerbation ABX treatment
Yes pseudomonas risk factors:
Used for majority of COPD exacerbations
(use pseudomonas risk factors, sputum cultures and patterns of resistance)
Yes pseudomonas risk factors:
Levo 750 IV,
or
Piper-Taz 4.5g IV
or
2g Cefepime/ceftazidime
Obstructive sleep apnea definition
a common disorder that is characterized by obstructive apneas and hypopneas due to repetitive collapse of the upper airway during sleep
Obstructive sleep apnea Treatment
Weight loss exercise Changing sleep position Avoid alcohol Avoid certain meds CPAP
Acute Bronchitis Causes
Majority are caused by virus:
Rhinovirus
Coronavirus
Influenza virus
RSV
Bacterial cases are rare <10%
Most common are:
Chlamydia pneumoniae
Mycoplasma pneumoniae
Bordetella pertussis
Acute Bronchitis Tx
OTC
Dextromethorphan
Guaifenesin
Inhaled beta agonists are used for patients with wheezing and
underlying pulmonary disease
ABX are not recommended empirically
DXM MOA
Reduces the need to cough
inhibits the cough reflex
(dextromethorphan)
Low dose codeine MOA
Reduces the need to cough
inhibits the cough reflex
Guaifenesin MOA
Thins mucus making it easier to cough up
Expectorant
Reflex stimulation
Stimulates the respiratory tract secretions, allowing ciliary movement to carry the loosened secretions upward
Direct stimulation
The secretory glands are stimulated directly to increase their production of respiratory tract fluids
dextromethorphan
Delsym (OTC) (antitussive)
inhibits the cough reflex
Contra:
Don’t use under 4 years old
within 14 days of MAOI’s
Interactions:
Hyperpyretic crisis with MAOI’s
Guaifenesin
Mucinex (expectorant)
Thins mucus making it easier to cough up
Dose: Swallow whole, take with full glass of water, Q 12, max of 2 tabs per day
Adverse:
GI Upset, Drowsiness, HA, rash
Influenza tx
Anti-virals within 48 hours of onset of symptoms
Oseltamivir (neuraminidase inhibitor)
Oseltamivir
Tamiflu (neuraminidase inhibitor)
Acute uncomplicated illness within 48hours
>2 weeks of age
Prophylaxis of influenza >1 yr old
(not a substitute for Vaccine)
> 13 y/o 75mg BID x5 days
Interactions:
Not for use with live vaccine with 2 weeks prior or 48 hours after treatment
Empyema treatment
Infections in the pleural space that are community acquired
3rd gen Cef + metronidazole
or ampicillin-sulbactam (monotherapy)
Hospital acquired infections or post pneumonia
Vanc + metronidazole and anti-pseudomonal cef (cefepime, ceftazidime)
Cor Pulmonale
Treat underlying cause of Pulmonary disease
Prostanoids
For pulmonary HTN
relax and open arteries in the lungs by
targeting the prostacyclin pathway
These meds increase the prostacycin in the body
Oral, IV or inhaler
Endothelin receptor antagonist
For pulmonary HTN
Reverses the effects of endothelin
Endothelin causes blood vessel narrowing
this allows the blood vessels to open allowing more blood flow
PDE-5 inhibitors
For pulmonary HTN
Blocks the action of PDE-5
PDE-5 causes the smooth muscles in the lungs to constrict.
PDE-5 stops this allowing the vessels to open and more blood flow to the lungs
Soluble guanylate cyclase stimulator
For pulmonary HTN
A chemical in the body that interacts with Nitric Oxide
This drug stimulates sGC which then interacts with NO and increases blood flow through the vessels of the lungs
Anti-coagulants
For pulmonary HTN
Helps prevent blood clots from forming
can increase risk of bleeding and can interact with other drugs, herbals, and foods.
Diuretics
For pulmonary HTN
Eliminates excess H2O this helps Pulmonary HTN by reducing the water and the amount of work the heart has to do
Epoprostenol
Flovan (prostacyclin analogue)
Pulmonary arterial HTN (WHO group 1)
Contra
HF due to reduced left ventricle ejection fraction
Interactions
Hypotensive effects may be potentiated by diuretics, anti-hypertensives, vasodilators
increased risk of bleeding with anti-coagulants, anti-platelets
ambrisentan
Letairis (Endothelin receptor antagonist)
Pulmonary arterial HTN (WHO group 1)
Contra
Pregnancy, idiopathic pulmonary fibrosis including those with pulmonary HTN (WHO group 3)
Box warning
Fetal toxicity
riociguat
Adempas (Soluble guanylate cyclase stimulator)
Pulmonary arterial HTN (WHO group 1)
To improve exercise capacity
Contra
Pregnancy, Nitrates or NO, PDE-5 inhibitors, Pulmonary HTN associated with idiopathic interstitial pneumonia
Box warning
Fetal toxicity
PE treatment
Low risk of bleeding
High clinical suspicion
Low risk of bleeding
High clinical suspicion
Empiric anticoagulation until definitive tests are complete
PE treatment
hemodynamically unstable
with definitive diagnosis
Systemic thrombolytic therapy
rather than empiric anti coagulation
Which of the below meds is a short-acting anticholinergic med for COPD?
albuterol (Ventolin)
tiotropium (Spriva)
ipratropium (Atrovent)
salmeterol (Serevent)
ipratropium (Atrovent)
Which medication is considered a long-acting muscarinic antagonist?
albuterol (Ventolin)
tiotropium (Spriva)
ipratropium (Atrovent)
salmeterol (Serevent)
tiotropium (Spriva)
Which medication is considered a long-acting beta agonist?
albuterol (Ventolin)
tiotropium (Spriva)
ipratropium (Atrovent)
salmeterol (Serevent)
salmeterol (Serevent)
Which medication is considered a short-acting beta agonist?
albuterol (Ventolin)
tiotropium (Spriva)
ipratropium (Atrovent)
salmeterol (Serevent)
albuterol (Ventolin)
What category of cough medicines is best for the drug, dextromethorphan?
Analgesics
Antitussive
Antihistamine
Expectorant
Antitussive
Idiopathic Pulmonary Fibrosis Treatment
Supportive care
Select meds (pirfenidone, nintedanib)
participation in clinical trials
Referral for lung transplant
Treatment of Comorbidities
Idiopathic Pulmonary Fibrosis Treatment
Mild to moderate
pirfenidone, nintedanib
if available in the area
nintedanib
Ofev (kinase inhibitor)
Idiopathic Pulmonary Fibrosis
Adverse
NVD, abdominal pain, Liver enzyme elevation, decreased appetite
nintedanib active ingredient
Tyrosine Kinase inhibitor
inhibits growth factor
pirfenidone
Esbriet (pyridone)
Idiopathic Pulmonary Fibrosis
Antifibrotic, anti-inflammatory, anti-oxidant
Suppression of Tumor necrosis factor & interleukin
Warnings
Perform liver function tests prior to initiating treatment, monthly for the first 6 months, and every 3 months thereafter.
Permanently discontinue if ALT/AST >3 – ≤5XULN with symptoms or hyperbilirubinemia,
or if ALT/AST >5XULN occurs
Pneumoconiosis Treatment
Supplemental O2 (liquid or compressed)
Bronchodilators - to open lung passages
Not smoking - can exacerbate symptoms
Avoid harmful dust and particles
Sarcoidosis Definition
Sarcoidosis is a multisystem disease of unknown etiology characterized by tissue infiltration with noncaseating granulomas.
The granulomas may occur in any organ, but the most frequently affected sites are the lungs, lymph nodes, skin, eyes, and liver.
Sarcoidosis Treatment
Glucocorticoids
Attenuate the granulomatous inflammatory process
Sarcoidosis Treatment
Refractory to steroids
methotrexate(MTX) or azathioprine,
Prior to initiating therapy withmethotrexate(MTX),azathioprine, orleflunomide,
baseline complete blood counts and serum aminotransferases, albumin, and creatinine are obtained
Methotrexate
Rheumatrex (DMARD)
Folic acid antagonist
Contra
Alcoholism, Chronic liver disease, immnuodeficiency, blood dyscrasias, Preg Cat X, Nursing mothers
Warning
Severe toxic reactions, Deaths have been reported
Only used by experienced MD’s
Inform patients of risks
Adverse
Elevated liver enzymes, NV, Rash, Thrombocytopenia, stomatitis
Why use methotrexate for sarcoidosis
Methotrexate is one of the most commonly used corticosteroid-sparing therapies for sarcoidosis,
due to its effectiveness, low cost and, at the dosages used to treat sarcoidosis, relatively low risk of side effects compared to other cytotoxic agents.
Folic acid and methotrexate
Check CBC Liver and kidney labs ever 1-3 months
Folic acid supplements may be used to reduce toxicity
azathioprine
Imuran (immunosuppressant) (antimetabolite)
Contra
RA, Pregnancy, prior use of alkylating agents
Warning
Malignancy
Increased risk of lymphoma
Skin cancer
Adverse
Leukopenia, thrombocytopenia, anemia
azathioprine (Imuran)
Most common side effects
Diarrhea abdominal cramping hair loss Liver enzyme elevation Bone marrow suppression
Silicosis Treatment
Supportive Smoking cessation Bronchodilators Flu and Pneumo vaccine Supplemental O2
Systemic glucocorticoids have been used to interrupt the inflammation that leads to progressive silicosis
Preferred Antibiotic
Strep pneumo
Pen G
Amoxicillin