Pharm of Posterior Pituitary Hormones Flashcards
ADH can be used to treat -_____ Diabetes Insipidus
Neurogenic/Central
Important details on V1 receptors
- Pressor effects. Lowered affinity for ADH.
IP3 coupled.
Important details on V2 receptors
Mediate anti-diuretic effects
cAMP coupled
On basolateral membrane of principal cells in collecting tubule and thick ascending limb
Effects of Prostaglandins on ADH
Inhibit antidiuretic action
NSAIDs can remove PG effects, potentiating ADG
Effects of Lithium on ADH
Inhibits ADH by inhibiting cAMP production via V2 receptors
Effects of Demeclocycline on ADH
Suppresses ADH action through attenuation of cAMP production
Four types of Vasopressin Agonist
Vasopressin Injection (Pitressin) Desmopressin Acetate (DDAVP) (V2 specific) Lypressin (Nasal Spray) Vasopressin Tannate (Suspended in peanut oil)
Vasopressin is used to treat…
Central DI
Esophageal variceal bleeding
Colonic Diverticular bleeding
Side effects of Vasopressin agonist treatmnet
Risk of Hyponatremia/Seizures
Risk with Coronary Artery Disease
Name the important vasopressin antagonists
Conivaptan HCl
Tolvaptan (Higher affinity for V2)
Demeclocycline
Why use a vasopressin antagonist?
Conivaptan + Tolvaptan –> SIADH
Relationship of placenta to Oxytocin breakdown
Secretes an aminopeptidase that degrades oxy and ADH
Why use Oxytocin?
Induce Labor, Manage uterine atony/hemorrhage
Used in oxytocin challenge test to assess effects of uterine contraction on fetus.
Contraindications for oxytocin
Fetal distress, abnormal fetal presentation
Predisposition to uterine rupture
name the oxytocin antagonist not approced in the US that acts as a treatment for preterm labor
Atosiban
