Corticosteroids

Question 1

Difference in the structure of a glucocorticoid and a mineralocorticoid

Answer 1

Cortisol (gluco) has a hydroxyl group and aldosterone does not

Question 2

Two major enzymes upregulated by glucocorticoids

Answer 2

PEPCK - Ups gluconeogenesis

Lipocortin1 - Suppresses phosphilipaseA2 (eiocosanoid synth)

Question 3

Main way glucocorticoids do immunosuppression

Answer 3

Activated GR binds to NfkB and prevents binding to response element. No gytokine genes are expressed

Question 4

Role of ketoconazole in this packet

Answer 4

Inhibits enzymes requred to make glucocorticoids

Can help treat cushings

Question 5

Name the short acting, intermediate, and long acting steroids

Answer 5

Shot – Cortisone, hydrocortisone
Inter – Prednisone, Methylprednisone, Prednisolone
Long – Dexamethasone, Betamethasone

Question 6

How is Fludrocortisone different from the other corticos

Answer 6

High MC activity, used as an aldosterone surrogate

Question 7

Important structural details on Triamcinoone

Answer 7

F raises MC, but 16-OH abolishes it while keeping the GC

High hydrophilicity and low oral bioavailability

Question 8

Which glucocorticoids are made for topical administration?

Answer 8

Triamcinolone acetonide, Betamethasone valerate
Cl - Clobetasol Propionate, Halobetasol pro., Halcinonide
Fluticasone propionate, Mometasone furoate

Question 9

Name the six inhaled glucocorticoids

Answer 9

Triamcinolone acetonide, Betamethasone valerate
Flunisolide, Budesonide
Fluticasone propionate, Mometasone furoate