Gastrointestinal drugs -- Overflow cards from the 2nd day of this lecture

Question 1

Chemotherapeutics are especially known for triggering activity at what brain site

Answer 1

area postrema

Question 2

Which part of the brain is the vomiting cener

Answer 2

nucleus of the solitary tract

Question 3

Four types of discussed anti-emetics

Answer 3

D2 dopamine receptor antagonists
Anticholinergics/Antihistamines
5-HT3 receptor antagonists
Cannabinoids

Question 4

Two examples of D2 receptor antagonist anti emetics

Answer 4

Promethazine (Phenergan)

Prochlorperazine (Compazine)

Question 5

Two examples of anti-emetic anticholinergic/antihistamine drugs

Answer 5

Meclizine (Antivert)

Scopolamine

Question 6

5-HT3 receptor antagonists include…

Answer 6

Ondansetron (Zofran)

Granisetron (Kytril)

Question 7

How do 5HT3 receptor blockers work as antagonists

Answer 7

Block CTZ and Vagal afferents from stomach and SI (which would activate the emetic centers)

Question 8

5HT3 receptor blockers are commonly combined with

Answer 8

Aprepitant (a NK antagonist)

Dexamethasone

Question 9

Important Cannabinoids used as anti-emetics

Answer 9

Dronabinol (Marinol)
Nabilone (Cesamet)
Synthetic THC