PHARM: Lung Cancer Flashcards
MOA of Carboplatin and Cisplatin.
DNA intrastrand crosslinking and adducts
MOA of Cyclophosphamide.
pro-drug of active alkylating moiety
MOA of docetaxel.
microtubule stabilizer inhibiting depolymerization
MOA of doxorubicin.
Intercalator, free radical generator, topo II inhibitor
MOA of etoposide.
DNA-topo II complex stabolizer
MOA of gemcitabine.
DNA polymerase inhibitor via incorporation of triphosphate form during DNA synthesis
MOA of ifosfamide.
intra-and inter-strand cross linker
MOA of irinotecan.
DNA-topo I complex stabilizer
MOA of paclitaxel.
microtubule stabilizer inhibiting depolymerization
MOA of pemetrexed.
DHFR inhibitor
MOA of topotecan.
DNA-topo I complex stabilizer
MOA of vincristine and vinorelbine.
Microtubule inhibitor (tubules disintegrate into spiral aggregates/protofilaments)
AE of carboplatin.
Allergy
Blood dyscrasia
Increased hepatic enzymes, BUN,a nd creatinine
AE of cisplatin
Allergy
Nephrotoxicity
Ototoxicity
AE of cyclophosphamide.
Hemorrhagic cystitis (MESNA protective)
Pulmonary fibrosis
Amenorrhea/infertility
Secondary malignancies
AE of docetaxel.
Increased mortality in NSCLC
Edema (steroids protective)
Sensory Neuropathy
AE of doxorubicin.
CHF
Hepatic Disease
Extravasational necrosis
Secondary malignancy
AE of etoposide.
Hematologic Toxicity
Alopecia
AE of gemcitabine.
arthralgia
alopecia
sensory peripheral neuropathy
AE of ifosfamide.
Alopecia
Blood dyscrasia
neurotoxicity
Hematuria renal failure
AE of irinotecan.
Weakness, pain, weight loss
AE of paclitaxel.
taxane hypersensitivity
myalgia and arthralgia
AE of pemetrexed.
GI toxicity (worse when combined with cipslatin in NSCLC) Elevated LFT and serum creatinine
AE of topotecan.
Hyperbilirubinemia
AE of vinblastine.
Neuropathic toxicity
FATAL (if intrathecal administration)
AE of vinorelbine.
Neutropenia
less neuropathic toxicity than vinblastine
MOA of methotrexate.
inhibits folic acid metabolism
AE of methotrexate.
stomatitis, pulmonary fibrosis, kidney failure