Pharm Lecture Notes

Question 1

What two cutaneous fungal infections require systemic therapy?

Answer 1

Onchomycosis
Tinea corporis
Tinea Mannus (palms only)

Question 2

Which inhibits first and last in the ergosterol synthesis pathway?

Answer 2

TNA

Question 3

When you see multi-drug resistance, what should you suspect as the cultprit?

Answer 3

Efflux Pumps are often responsible for MDR

Question 4

Griseofulvin
• Fungicidal?
• Side effects?

Answer 4

Griseofulvin is Fungistatic

Causes a disulfram-like effect

Question 5

What are some drugs that have a well established disulfram-like effect?

Answer 5

Metronidazole
Clorpropamide
Tobutamide
Cephalosporins

Question 6

Why is Terbinafine so hepatotoxic?

Answer 6

It acts on Epoxidation enzymes in the fungus. Epoxidation is an important function of CYP enzymes so we see similar inhibition.

Question 7

Where are VAMPs found?

Answer 7

These are on the inner layer of the synaptic membrane to interact with SNAREs

Question 8

What makes oxybutynin different than Glycopyrrolate and Propanolol?

Answer 8

It crosses the BBB easily