Pharm II Final Exam Crossword Flashcards
Name the species in which penicillins should generally not be used orally:
guinea pigs
If you cannot do a full culture you can still use this quick test to gain useful information:
Gram Stain
Broad spectrum antibiotic that induces microsomal enzymes and to which resistance develops rapidly:
rifampin
A macrolide antibiotic that is also used as a GI prokinetic
erythromycin
A carbapenem antibiotic that is used subcutaneously:
meropenem
Fluoroquinolones inhibit function of this enzyme:
DNA Gyrase
Acts on the 30S ribosomal subunit and can cause yellow discoloration of teeth in young animals:
Tetracycline
Antibiotics that act as cationic detergents to disrupt cell membranes:
polymyxin
Antimicrobial resistance due to mutation within the microbe:
chromosomal
The major toxicities seen with aminoglycosides are ototoxicity and _______
nephrotoxicity
Resistance that is due to normal lack of the antimicrobial target in the bacteria:
intrinsic
Class of antibiotics that are good against gram- negative bacteria as well as mycoplasma:
fluoroquinolones
Pus is so rich in this that it can overcome the action of sulfonamides:
PABA
A natural penicillin that should not be given IV:
Penicillin G
Banned in food producing animals due to risk of aplastic anemia in humans:
chloramphenicol
One of the most common adverse effects seen with sulfonamide use in dogs:
keratoconjunctivitis sicca
This class of antibiotics is synergistic with penicillins in vivo but incompatible in vitro:
aminoglycosides
Streptogramins work on the ____ subunit of the ribosome
50s
Clindamycin is a member of this subclass of antibiotics that has good anaerobic activity:
lincosamides
Specific treatment for tritrichomonas in felines:
ronidazole
A last resort antibiotic for MRSA in humans that prevents attachment of the ribosome to mRNA:
linezolid
A cell-wall disrupting antibiotic that is often used topically to avoid toxicity:
bacitracin
Azithromycin and some other macrolides have extended effects due to accumulation in these:
phagocytes
Ormetoprim is an example of a drug that inhibits this:
dihydrofolate reductase
Often used with other antibiotics for anaerobic infections and also has immunomodulatory effects:
metronidazole
The lowest antimicrobial concentration at which bacterial replication is halted:
MIC
A beta-lactamase inhibitor commonly combined with amoxicillin:
clavulanic acid

A first-generation cephalosporin used intramammary for mastitis in cattle:
cephapirin
High urinary excretion (~50%) and more effective in acidic urine:
nitrofurantoin
A third generation cephalosporin that is a pro-drug ester converted to the active ingredient after absorption:
cefpodoxime
A topical antibiotic that can be useful against MRSA/MRSP and used for decolonization in humans:
mupirocin
A tetracycline that is usually used orally but can cause esophageal irritation:
doxycycline
A macrolide that can cause cardiac issues if given IV:
tilmicosin
Novobiocin activity against gram positive bacteria is (good/poor):
**good **