Pharm II Final Exam Crossword

Question 1

Name the species in which penicillins should generally not be used orally:

Answer 1

guinea pigs

Question 2

If you cannot do a full culture you can still use this quick test to gain useful information:

Answer 2

Gram Stain

Question 3

Broad spectrum antibiotic that induces microsomal enzymes and to which resistance develops rapidly:

Answer 3

rifampin

Question 4

A macrolide antibiotic that is also used as a GI prokinetic

Answer 4

erythromycin

Question 5

A carbapenem antibiotic that is used subcutaneously:

Answer 5

meropenem

Question 6

Fluoroquinolones inhibit function of this enzyme:

Answer 6

DNA Gyrase

Question 7

Acts on the 30S ribosomal subunit and can cause yellow discoloration of teeth in young animals:

Answer 7

Tetracycline

Question 8

Antibiotics that act as cationic detergents to disrupt cell membranes:

Answer 8

polymyxin

Question 9

Antimicrobial resistance due to mutation within the microbe:

Answer 9

chromosomal

Question 10

The major toxicities seen with aminoglycosides are ototoxicity and _______

Answer 10

nephrotoxicity

Question 11

Resistance that is due to normal lack of the antimicrobial target in the bacteria:

Answer 11

intrinsic

Question 12

Class of antibiotics that are good against gram- negative bacteria as well as mycoplasma:

Answer 12

fluoroquinolones

Question 13

Pus is so rich in this that it can overcome the action of sulfonamides:

Answer 13

PABA

Question 14

A natural penicillin that should not be given IV:

Answer 14

Penicillin G

Question 15

Banned in food producing animals due to risk of aplastic anemia in humans:

Answer 15

chloramphenicol

Question 16

One of the most common adverse effects seen with sulfonamide use in dogs:

Answer 16

keratoconjunctivitis sicca

Question 17

This class of antibiotics is synergistic with penicillins in vivo but incompatible in vitro:

Answer 17

aminoglycosides

Question 18

Streptogramins work on the ____ subunit of the ribosome

Answer 18

50s

Question 19

Clindamycin is a member of this subclass of antibiotics that has good anaerobic activity:

Answer 19

lincosamides

Question 20

Specific treatment for tritrichomonas in felines:

Answer 20

ronidazole

Question 21

A last resort antibiotic for MRSA in humans that prevents attachment of the ribosome to mRNA:

Answer 21

linezolid

Question 22

A cell-wall disrupting antibiotic that is often used topically to avoid toxicity:

Answer 22

bacitracin

Question 23

Azithromycin and some other macrolides have extended effects due to accumulation in these:

Answer 23

phagocytes

Question 24

Ormetoprim is an example of a drug that inhibits this:

Answer 24

dihydrofolate reductase

Question 25

Often used with other antibiotics for anaerobic infections and also has immunomodulatory effects:

Answer 25

**metronidazole**

Question 26

The lowest antimicrobial concentration at which bacterial replication is halted:

Answer 26

**MIC**

Question 27

A beta-lactamase inhibitor commonly combined with amoxicillin:

Answer 27

**clavulanic acid**

Question 28

A first-generation cephalosporin used intramammary for mastitis in cattle:

Answer 28

**cephapirin**

Question 29

High urinary excretion (~50%) and more effective in acidic urine:

Answer 29

**nitrofurantoin**

Question 30

A third generation cephalosporin that is a pro-drug ester converted to the active ingredient after absorption:

Answer 30

**cefpodoxime**

Question 31

A topical antibiotic that can be useful against MRSA/MRSP and used for decolonization in humans:

Answer 31

**mupirocin**

Question 32

A tetracycline that is usually used orally but can cause esophageal irritation:

Answer 32

**doxycycline**

Question 33

A macrolide that can cause cardiac issues if given IV:

Answer 33

**tilmicosin**

Question 34

Novobiocin activity against gram positive bacteria is (good/poor):

Answer 34

**good **