PHARM - Headache & NMJ Disorders Flashcards
drugs used to treat LEMS fit into what major categories?
list the drugs in each.
- K+ channel blockers
- amifampridine (3,4 - diamanopyridine)
- guanidine HCl
- AChE inhibitor
- pyridostigmine
- immunosupressants
- prednisone
- azothioprine
- anti-AChE Abs: IVIG, rituximab
drugs used to treat myasthenia gravis fit into what major categories?
list the drugs in each.
- AChE inhibitor
- pyridostigmine
- neostigmine
- physostigmine
- immunosupressants
- prednisone
- azothioprine
- anti-AChE Abs: IVIG, rituximab
what is the _mainstay treatment_s for LEMS
- amifampridine (3,4 diaminopyridine) - 1st line
- pyridiostigmine - if in conjunction with amifampridine
amifampridine
- clinical use
- MOA
- PK
- AEs / CIs
- clinical use: LEMS - first line
- MOA: K+ channel inhibition on NMJ pre-synapse
- hyperpolarization prevention
- pre-synaptic membrane depolarized for longer
- Ca++ release > P/Q channel blockage
- ACh released
- PK
- good gut absorption
- deactivated by N-acyltransferase
- AE / CI:
- AE
- tingling / numbness
- insomnia
- seizures
- CI:
- EPILEPY
- AE
when is amifampridine contraindicated?
with epilepsy
how is amifampridine deactivated?
by an N-acetyltransferase reaction
guanidine hydrochloride
- clinical use
- MOA
- AE/CI
- clinical use: LEMS - NOT first line (avoided unless absolutely necessary)
- MOA: K+ efflux inhibition
- AEs:
- bone marrow suppresion
- renal toxicity
pyridostigmine
- clinical use
- MOA
- AES
- PK
- clinical use:
- LEMS (as an adjunctive)
- myasthenia gravis
- MOA: AChE inhibitor - inceases ACh at NMJ
- AES: d/t systemic excess of ACh
- diarrhea, cramping, N & V
- possible cholinergic crsisis
- PK: reversible & short duration (3-4 hrs)
contrast the role of AChE inhibitors in the treatment of LEMS vs myasthenia gravis
i.e., pyridostigmine
- LEMS - effective with amifampridine
- myasthenia - is effective alone
weakness in LEMS is due to decreased ACh release from the pre-synapse, so is best treated by increasing ACh release rather than slowing ACh breakdown
what is the tensilon test & its clinical use?
- distinguishes between myasthenia crisis & cholinergic crisis
- test: administration of endrophonium, an AChE inhibitor
- paralysis improves: myasthenia crisis
- paralysis worsens: cholinergic crisis
- test: administration of endrophonium, an AChE inhibitor
which immuno-suppressants can be used to treat LEMS & myasthenia gravis?
when are they utilized?
used ONLY in refractory myasthenia gravis / LEMS.
-
prednisone +/- cycling with azothioprine
- prenidone - most effective, but most toxic
- azothioprine - steroid sparing
- other steroid sparing agents
- rituximab
- plasma exchange / IVIG
what are the treatments for botulism?
- anti-toxin: always used
- Abx (penicillin G, metronidazole) for wound botulism after anti-toxin administration
botulism anti-toxin
- MOA
- variations
- MOA: circulates in blood, blocking actions of toxin from C. tetanus
- comes in two variations:
- for pts < 1 year: human-derived botulisam immune globulin (BIV-G)
- for pts > 1 year: equine serum heptavalent botuslim antitoxin
BIG-IV should be given to which patients with botulism?
those < 1 year of age
what is the role of antibiotics in the treatment of botulism?
-
recommended: for wound botulism after anti-toxin administration
- penicillin G
- metronidazole (if b-lactam allergies)
- NOT recommended: for GI botuslism; i.e., no oral Abx - lyse cells
- contraindicated: aminoglycosides - are presynaptic NMJ blockers
why are oral Abx not recommended in the management of botulism?
Abx work by lysing cells, which could serve to increase toxin levels in the body
why are aminoglycosides C/I in the treatment of botulism?
they are NMJ blockers at the pre-synapse
what are the two major goals when treating headaches?
- to reduce acute pain
- to provide prophylaxis
which drugs are used in the treatment of acute headache?
- acetaminophen / NSAIDS
- triptans
- lasmiditan
- ergot alkaloids
- CGRP antagonist
triptans
- what kind of drug
- clinical use
- MOA
- PK
- AEs / CIs
- 5-HT1 agonists
- clinical use: acute headache
- MOA: bind to 5-HT1B & 5-HTD1 receptors on cranial vessels outside the CNS
- 5-HT1B stimulation: vasoconstiction
- 5-HT1D stimulation: inhibition of vasoactive peptides release
- PK: metabolism into naratripan by
- CYP-1A2
- CYP-3A4
- MAO
- AEs/CI:
- AEs: cardiovascular (rare)
- MI
- HTN
- arrytmias
- angina
- CI: MAO inhibtors
- AEs: cardiovascular (rare)
what are the adverse affects of triptan?
all cardiovascular (due to vasoconstriction)
- MI
- HTN
- arrtyhmias
- angina
triptans are contraindicated with what drug? why?
MAO inhibitors
MAO-A is needed to metabolize triptans into naratriptan for excretion