Pharm- Geriatrics

Question 1

Cholinesterase inhibitors- Names

Answer 1

Donepezil (aricept), Tacrine (cognex), Rivastigmine (exelon), Galantamine (Razadyne)

Question 2

Cholinesterase inhibitors- Indication

Answer 2

Alzheimer dementia

Question 3

Cholinesterase inhibitors-MOA

Answer 3

• Inhibits acetylcholine breakdown

- Increasing level and duration of action of neurotransmitter

Question 4

Cholinesterase inhibitors- AE/CI

Answer 4

• Nausea, diarrhea
• Orthostasis
• Urinary incontinence
• Myalgias
• Tremors

Question 5

Cholinesterase inhibitors- Pt ed

Answer 5

Palliative only, doesn’t cure or prevent

Question 6

Memantine (Namenda)- MOA

Answer 6

• NMDA Receptor agonist

- Slows influx of Ca

Question 7

Memantine (Namenda)- Indications

Answer 7

• Used in combination with cholinesterase inhibitors

- Dementia, alzheimers

Question 8

Memantine (Namenda)- AE/CI

Answer 8

• Dizziness, HA, confusion, constipation,

Question 9

Tolterodine tartae (Detrol LA)- MOA

Answer 9

• Anticholinergic
• Relaxes bladder smooth muscle
• Inhibits involuntary contractions

Question 10

Tolterodine tartae (Detrol LA)-Indications

Answer 10

• Overactive bladder

- Incontinence, except obstructive

Question 11

Tolterodine tartae (Detrol LA)- AE/CI

Answer 11

• CNS effects (drowsy, confusion), dry mouth

- Anaphylaxis, angioedema

Question 12

Tolterodine tartae (Detrol LA)- Pt ed

Answer 12

Cause delirium and dementia

Question 13

Oxybutynin (Ditropan)- MOA

Answer 13

• Antispasmodic & anticholinergic

- Inhibits detrusor muscle contractions

Question 14

Oxybutynin (Ditropan)- Indications

Answer 14

Overactive bladder

- Incontinence

Question 15

Oxybutynin (Ditropan)- AE/CI

Answer 15

• Dry mouth, dizziness, constipation, somnolence