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DPT710A: Pharmacology > Pharm Final: Coagulation and Dislipidemia > Flashcards

Pharm Final: Coagulation and Dislipidemia Flashcards

1
Q

Select the clotting disorder:
Hate clotting

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

a. Hemophilia

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2
Q

Select the clotting disorder:
Love clotting

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A
  • b. Inherited Hypercoagulable States

c. Acquired Hypercoagulable States

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3
Q

Select the clotting disorder:
Factor V Leiden

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

b. Inherited Hypercoagulable States

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4
Q

Select the clotting disorder:
Factor II, VII, VIII, XI deficiency

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

a. Hemophilia

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5
Q

Select the clotting disorder:
Prothrombin gene mutation (20210a)

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

b. Inherited Hypercoagulable States

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6
Q

Select the clotting disorder:
Cancer

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

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7
Q

Select the clotting disorder:
Recent Trauma or Surgery

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

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8
Q

Select the clotting disorder:
Pregnancy

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

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9
Q

Select the clotting disorder:
Hormone replacement therapy or oral contraceptive use

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

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10
Q

Select the clotting disorder:
Elevated levels of fibrinogen

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

b. Inherited Hypercoagulable States

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11
Q

Select the clotting disorder:
Von Willebrand disease

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

a. Hemophilia

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12
Q

Select the clotting disorder:
HIT (Heparin Induced Thrombocytopenia)

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

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13
Q

Select the clotting disorder:
Antiphospholipid antibody syndrome

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

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14
Q

Select the clotting disorder:
Deficiencies of protein C and S

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

b. Inherited Hypercoagulable States

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15
Q

Select the clotting disorder:
Hyperhomocysteinemia

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

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16
Q

Select the clotting disorder:
Elevated levels of Factor VIII

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

b. Inherited Hypercoagulable States

17
Q

Select the clotting disorder:
Previous deep vein thrombosis or pulmonary embolism

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

18
Q

Select the clotting disorder:
Myeloproliferative disorders such as polycythemia vera or essential thombocytosis

a. Hemophilia
b. Inherited Hypercoagulable States
c. Acquired Hypercoagulable States

A

c. Acquired Hypercoagulable States

19
Q

PE vs. DVT?

A

Deep Vein Thrombosis: clot in the venous system (usually legs)

Pulmonary Embolism: clot in the pulmonary veins (commonly emboli from a DVT)

20
Q

PE vs. DVT therapy implications?

A

DVT: leg pain, swelling, or may be asymptomatic
PE: Shortness of Breath, chest pain, cough

21
Q 
Herparin
Uses:
Purpose:
Mechanism of Action:
Side Effects:
A 
Herparin
Uses: First line use--> very fast onset and elimination
-ACS
-Atrial fibrillation
-Medical and Surgical VTE prophylaxis
-Prosthetic heart valves
-Traume
-Venous thromboembolism

Purpose: prevents clot formation

Mechanism of Action: by controlling function and synthesis of clotting factors

Side Effects: bleeding, thrombocytopenia (decreased platelets)

  • Not orally available, can only be given IV or subcutaneously
  • Derived from pork
  • Protamine sulfate is reversal agent
22
Q

What is Heparin induced thrombocytopenia (HIT)?

A

Profound thrombocytopenia secondary to heparin use: fall in platelets

  • platelet drop occurs 5-10 days after heparin exposure
  • drop can occur within a day if patient previously exposed to heparin
  • “Heparin allergy” designation once patient experiences HIT
23
Q 
Warfarin
Purpose:
Side Effects:
Mechanism of Action:
Reversal Agent:
A 
Warfarin
Purpose: 
-Prophylaxis of venous thrombosis (high-risk surgery)
-Treatment of VTE
-Prevention of systemic embolism
-Acute MI
-Valvular heart disease
-Atrial Fibrillation
-Heart valves (tissue, mechanical)
-Anti-phospholipid Antibody Syndrome

Side Effects: bleeding, skin necrosis

Mechanism of Action: reduces vitamin L (there are 4 k-dependent clotting factors)

Reversal Agent: vitamin k

24
Q

P2Y12 Inhibitors
Purpose:
Side Effects:
Mechanism of Action:

A

P2Y12 Inhibitors
Purpose: use with aspirin for at least 1 year in patients who are post-ACS, undergoing PCI, and sometimes CABG

Side Effects: bleeding, headache, dyspnea (ticagrelor only)

Mechanism of Action: amplified and stabilizes ADP-induced platelet aggregation

25
Q

Thrombolytics
TPA?
Use:
Purpose:

A

TPA = tissue plasminogen activator: helps breakdown clots

Use: Stroke (alteplase only)
AMI
Massive PE
Catheter Clearance (alteplase only)

Purpose: break down already formed thrombus –> reestablishes blood flow

26
Q

Statins
Theraputic Use:
MOA:
Side Effects:

A

Statins
Theraputic Use: Dyslipidemia, Post MI, Primary prevention of CVD (work best if given at bed time)

MOA: Decrease cholesterol production, increase LDL breakdown, decrease VLDL production, plaque reduction, antioxidant effects and antithrombotic effects

Side Effects: Headache, GI, Myalgia, rhabdomyolysis (rare but serious)

DPT710A: Pharmacology (8 decks)

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