Pharm Exam 1 Final Flashcards
Where is DEA number found on a prescription?
The closing
What is the purpose of a black box warning?
To draw attention to being potentially fatal.
Schedule 3 drugs can be what?
Telephoned in and refills are no more than 5 times in a 6 month period.
Schedule 2 drugs need
A written prescription
A drug can have only___ generic name and _________ trade names.
1 generic
Several trade
Herbs can cause
Adverse effects
A drug biologically active can do what?
Modify cellular function
A dose response curve for a more efficacious drug will have what?
Greater curve height
Therapeutic index ratio
Median lethal dose to median effective dose
Drugs competing for the same receptor
Drug with stronger affinity for the receptor will bind to more receptor than drug with weaker affinity.
A drug that has an affinity for a receptor and produces no effect?
Competitive antagonist
A substance is transported against concentration gradient is know as what?
Active transport
Half-life is related to what?
Duration
Where is the most common site for bio transformation?
Liver
A drug with zero-order elimination kinetics means what?
Constant amount of the drug is eliminated and is retained in the body.
Patients perception that a pill without active ingredient is having a pharmacological effect is what?
Placebo Effect
Hypersensitivity reaction that causes antibody antigen deposition?
Type 3
True or False? Drug A and drug B have same ED 50, Drug B has a wider TI; therefore drug A has a greater LD 50 than B.
First statement True
Second statement False
SLUD is the adverse reactions for
cholinergic
What does the S stand for in SLUD
Salivation
Which statement is most correct concerning the sympathetic autonomic nervous system (SANS)?
A) Multiple preganglionic fibers synapse with a single postsynaptic neuron to produce a localized effect.
B) A single preganglionic fiber often synapses with numerous postganglionic neurons to produce a diffuse effect.
C) Multiple preganglionic fibers synapse with a multiple postsynaptic neurons to produce a localized effect.
D) A single preganglionic fiber often synapses with single postganglionic neurons to produce a diffuse effect.
B
What is the preganglionic neurotransmitter of the parasympathetic nervous system?
Acetylcholine
Which naturally occurring cholinergic agents is given to stimulate saliva flow?
pilocarpine
Which statements are true about the preganglionic fibers of the PANS?
A.) Preganglionic fibers are relatively long and extend near to or into the innervated organ.
B.) A low ratio of synaptic connections between preganglionic and postganglionic neurons usually exists, leading to a discrete or more localized response when the PANS is stimulated.
C.) Postganglionic fibers are usually short and terminate on the innervated tissue.
D.) Nerve distribution is complex for the third, seventh, and ninth cranial nerve and is relatively simple for the tenth or vagus nerve.
E.) All of these statements are true. Incorrect
F.) Only a, b, and c are true.
F
What schedule of drug is most abusive
I
This schedule of drugs may not be refilled more than five times in 6 month period
Schedule III-IV
A biologically active substance that can modify cellular function
Drug
Undesirable response to drug; potentially harmful; occurs at usual therapeutic doses
Adverse reaction
A drug may have more than one generic name, but only one trade or propriety name
Both statements are false
Ganglions of parasympathetic autonomic system
long preganglionic neurons to short postganglionic
These are associated with PANS
Cranial nerves and sacral segments of spinal cord
When a higher dose of a drug causes he same effect
Drug tolerance
The type of administration of a drug effects the onset and duration of the response
TRUE
An effect of a drug that is not predictable or dose related
Drug allergy
A non therapeutic action
IS NOT FOR TARGET TISSUES
When is a fetus most at risk of the mom is taking meds
Before pregnancy status is known
Life threatening hypersensitivity
Type 1
Immune complex sensitivity
Type 3
Delayed hypersensitivity
4
A dose of meds hat kills 50 % of the animals
Lethal dose 50
LD50
The LD50 of drug A and drug B is the same but the therapeutic index is wider and that makes drug A toxic dose greater than drug B
The first statement is true the second statement is false
If a pt has a suspected adverse reaction what is the first thing you should do
Ask what meds they’re taking
An allergy and a side effect are examples of a dose related response
FALSE
Tetracycline NSAIDS and benzocaine are safe while pregnant
FALSE
The greater the therapeutic index the greater the toxicity
FALSE
The autonomic nervous system functions as ____ for bodily functions
Autonomic modulating
A reaction that is neither the drug’s side effect nor an allergic reaction
Idiosyncratic reaction
Which does not raise the pain threshold?
Prostaglandins
