PHARM: Depression/ADHD/Antipsychotics/Mood Stabilizers/Sedatives

Question 1

Anti-depressants that prevent pre-synaptic uptake of amines (noradrenaline/serotonin)?

Answer 1

Question 2

Anti-depressants that block reuptake of serotonin?

Answer 2

Question 3

Anti-Depressants that reduce activity of monoamine oxidase in breaking down pre-synaptic amines => more available for synaptic release

Answer 3

Question 4

Anti-depressants that block post-synaptic receptors directly?

• Indications?
• Cautions?

Answer 4

Question 5

What is the Monoamine Hypothesis?

Answer 5

In depression, there is a deficiency of NORADRENALINE and SEROTONIN

Question 6

Tricyclic Antidepressants (TCAs)

• 5-HT Selective?
• Noradrenaline Specific?
• Overdose Risk/Side Effects?

Answer 6

Question 7

Vortioxetine

• MOA
• Indications/Advantages

Answer 7

Question 8

First-line treatment for ADHD?

Second-line?

Answer 8

Question 9

___________ (Non-Stimulant ADHD Med) has a direct effect on post-synaptic α2A-adrenergic receptors

Answer 9

Guanfacine has a direct effect on post-synaptic α2A-adrenergic receptors

Question 10

Benzodiazepines

• Indications
• Examples
• MOA
• Misuse/Reversal Agent?

Answer 10

Question 11

Lithium

• MOA
• Side Effects
• Cautions

Answer 11

Question 12

Drug indicated for treatment-resistant Schizophrenia?

• Side Effects?

Answer 12

Question 13

First gen vs. Second Gen Antipsychotics

• Side Effects
• Examples

Answer 13

Question 14

Mood Stabilizers for Treatment of Bipolar Disorder?

Answer 14

Question 15

Benzodiazepine/Z Drug Reversal Agent?

Answer 15

Flumazenil