PATH: Neurodegenerative Disorders Flashcards
System Degeneration for each disease:
- Dementia
- Huntington’s
- Parkinson’s
- Motor Neuron Disease?
In Alzheimer’s disease, ____________ precedes structural change
In Alzheimer’s disease, Functional Impairment precedes structural change (loss of neurons)!!
What Neurodegenerative disease is Down’s Syndrome Associated with?
Alzheimer-Amyloid Cascade Model?
Altheimer Amyloid Tau Model?
Presentation of FrontoTemporal Dementia?
On which chromosome is the Tau Regulating Gene?
Chromosome 17
On which chromosome is the Gene responsible for Huntington’s?
Chromosome 4: CAG Repeats
Major genetic cause of Amyotrophic lateral sclerosis (ALS).
What can this progress to?
C9orf72 Repeat Expansion => aberrant expression of aggregation-prone proteins (Neurotoxic BEFORE inclusions appear)
C9 associated with both ALS and Frontotemporal Dementia
Management of patients w/ ALS?
Manifestations of Parkinson’s Disease? Motor/Non-Motor?
Pathological Apearance of Parkinson’s Disease?
Positive/Negative Signs of Movement Disorders?
Parkinsonism vs. Chorea?
