PATH: Tumors of CNS

Question 1

Locations of Pediattric vs. Adult Brain tumors?

Answer 1

70% of ped tumors in Posterior Fossa

70% of Adult tumors are in Cerebral Hemispheres

Question 2

Histogenesis of tumours: Gliomas vs. Non-Glioma

Answer 2

Gliomas: Glial Fibrillary Acidic Protein (GFAP) Positive

Non-Glioma: Synaptophysin Positive

Question 3

Classifications of CNS Tumors?

Answer 3

Tumors are defined acording to appearance, growth, grade, location and mutations

Question 4

Commonest glioma in children that manifests as a circumscribed astrocytic glioma with Rosenthal Fibers?

Answer 4

Question 5

Diffuse Astrocytoma affecting young adults (30-40) appearing diffuse on imaging?

Answer 5

Question 6

Brain tumor presenting with a fried egg appearance (40-50-Year-olds)

Answer 6

Question 7

Most common primary brain tumor in adults that involves necrosis and endovascular proliferation. Appear as ring enhancing lesions on imaging and is resistant to Treatment (WHY?)

Answer 7

Question 8

Brain tumor affecting children (~7 Years old) consisting of blastoma (immature cells) and Homer Wright Pseuosettes spread along the CSF (Dropped Mets)?

Answer 8

Question 9

Tumor of nerve sheath presenting in 4th-6th decades and which can lead to an acoustic neuroma (CN VIII Impacted) GENETICS?

Answer 9

Question 10

Tumor composed of mauture neoplastic swann cells plus non-neoplastic perineurial cells and fibroblast like cells. GENETICS?

Answer 10

Question 11

Tumor affecting the inner surface of dura mater (Orbital/spinal) GENETICS?

Answer 11

Question 12

Tumor which impairs CSF => Raised ICP and may secrete EPO => Polycythemia. Associated with von Hippel Lindau Syndrome

Answer 12

Question 13

Tumor which is common to immunosuppressed (6-7th decade immunocompetent) associated w/ EBV/HIV?

Answer 13

Question 14

Tumor occurring in childhood casued by remanants of Rathke’s Pouch?

Answer 14

Question 15

How would a right sided Brown Sequard Lesion Present?

Answer 15

Question 16

Degenetative cyst that develops in the spinal cord (Often cervical) resulting in a cape-like loss of pain?

UMN and LMN Effects?

Answer 16

Question 17

Downward displacement of cerebellum due to enlarged foramen magnum bc of underdevelopment of skull?

Signs?

Answer 17

1. Tonsilar Herniation
2. Elongated Brain Stem
3. Small 4th Ventricle
4. Tectal Breaking
5. Hydrocephalus

Question 18

Enlargement of the posterior fossa resulting in slow motor development, hydrocephalus (excessive CSF) and cephalomegally (Large head)

Answer 18