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Med School > Pharm Block 3 (antibiotics) > Flashcards

Pharm Block 3 (antibiotics) Flashcards

1
Q

Penicillin G

A

Penicillin, IV, IM, used for gram+- cocci, spirochetes, anaerobes of oral cavity, not resistant to penicillinase
Adverse: All kinds of allergies, high doses cause convulsions

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2
Q

Penicillin V

A

Penicillin, PO very available, used for gram+- cocci, spirochetes, anaerobes of oral cavity, not resistant to penicillinase
Adverse: all kinds of allergies, high doses cause convulsions

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3
Q

Dicloxacillin

A

Penicillinase resistant, treat S. aereus except MRSA

Adverse: high causes convulsions

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4
Q

Nafcillin

A

Penicillinase resistant, S. aereus except MRSA, primarily excreted in the bile
Adverse: high causes convulsions

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5
Q

Oxacillin

A

Penicillinase resistant, S. aereus except MRSA

Adverse: high causes convulsions

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6
Q

Methicillin

A

Penicillinase resistant, S. aureus except MRSA

Adverse: high causes convulsions

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7
Q

Ampicillin

A

Amino penicillin, same as penicillin and wider (E. coli, H. influenza, Salmonella, Shigella and some Proteus, penicillinase sensitive (use with penicillinase inhib)
Adverse: high causes convulsions

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8
Q

Amoxicillin

A

Amino penicillin, penicillin but wider (E. coli, H. influenza, Salmonella, some proteus), use with peniciliinase inhib (penicillinase sensitive), more PO available than ampicillin
Adverse: high causes convulsions

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9
Q

Carbenicillin indanyl

A

Antipseudomonal penicillin, same as penicillin but wider (gets Pseudomonas and gram- rods), penicillinase sensitive (use with penicillinase inhib)
Adverse: high causes convulsions

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10
Q

Ticarcillin

A

Antipseudomonal penicillin, same as penicillin but wider (gets Pseudomonas and gram- rods), penicillinase sensitive (use with penicillinase inhib)
Adverse: can cause coag inhib and electrolyte imbalance (2X Na in prep)
Adverse: high causes convulsions

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11
Q

Piperacillin

A

Antipseudomonal penicillin, same as penicillin but wider (gets Pseudomonas and gram- rods), penicillinase sensitive (use with penicillinase inhib), gets Klebsiella
Adverse: high causes convulsions

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12
Q

Clavulanic acid

A

Penicillinase inhib

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13
Q

Sulbactam

A

Penicillinase inhib

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14
Q

Tazobactam

A

Penicillinase inhib

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15
Q

Cephalexin

A

1rst gen cephalosporin, Gram+ cocci, E. coli, K. pneumonia, P. mirabilis, gm+ penicillinase resistant, gm- penicillinase sensitive
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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16
Q

Cefazolin

A

1rst gen cephalosporin, Gram+ cocci, E. coli, K. pneumonia, P. mirabilis, gm+ penicillinase resistant, gm- penicillinase sensitive, used for surgery prophylaxis, has a long half life (renal filtration)
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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17
Q

Cefaclor

A

2nd gen cephalosporin, gram+ cocci, H. influenza, Enterobacter aerogenes, Neisseria, P. mirabilis, E. coli, K. pneumonia, Serratia marcescens, gm+ penicillinase resistant, gm- penicillinase sensitive
Adverse: Serum sickness in kids
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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18
Q

Cefuroxime

A

2nd gen cephalosporin, gram+ cocci, H. influenza, Enterobacter aerogenes, Neisseria, P. mirabilis, E. coli, K. pneumonia, Serratia marcescens, gm+ penicillinase resistant, gm- penicillinase sensitive
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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19
Q

Cefotetan

A

2nd gen cephalosporin, only one good against Bacillis fragilis, gram+ cocci, H. influenza, Enterobacter aerogenes, Neisseria, P. mirabilis, E. coli, K. pneumonia, Serratia marcescens, gm+ penicillinase resistant, gm- penicillinase sensitive
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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20
Q

Ceftazidime

A

3rd gen cephalosporin, all other cephalosporin and serious gram- infections
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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21
Q

Ceftriaxone

A

3rd gen cephalosporin, all other cephalosporin and serious gram- infections, primarily biliary excreted
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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22
Q

Cefotaxime

A

3rd gen cephalosporin, all other cephalosporin and serious gram- infections
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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23
Q

Cefepime

A

4th gen cephalosporin, same as other cephalosporins but with more resistance to penicillinase and increased activity against pseudomonas
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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24
Q

Ceftaroline

A

5th gen cephalosporin, Active against MRSA, only beta-lactam that does
Adverse: Cross allergy with penicillin (10%), VitK deficiency (bleeding), no EtOH (disulfuran-like rxn)

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25
Q

Imipenem with cilastin

A

Carbapenem, gram+ cocci, gram- rods

Adverse: GI distress, skin rash, CNS toxicity (seizures) at high levels

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26
Q

Meropenem

A

Carbapenem gram+ cocci, gram- rods

Adverse: GI distress, skin rash, CNS toxicity (seizures) at high levels

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27
Q

Ertapenem

A

Carbapenem, gram+ cocci, gram- rods

Adverse: GI distress, skin rash, CNS toxicity (seizures) at high levels

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28
Q

Aztreonam

A

Monobactam, only aerobic gm- bact, very resistant to beta-lactamase, no cross allergies, used mainly for nosocomial gm- infs

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29
Q

Vancomycin

A

Glycopeptide, used gm+ only, for drug resistant bugs (MRSA and C. diff)

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30
Q

Telavancin

A

Lipoglycopeptide, complicated skin infections (MRSA)

Adverse: allergic? nephro and ototoxic? Don’t give it to preggers

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31
Q

Bacitracin

A

Cell well synth inhib, only used topically, very nephrotoxic

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32
Q

Cycloserine

A

Cell wall synth inhib, used in TB, inhibs alanine racemase preventing L-Ala to D-Ala

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33
Q

Fosfomycin

A

Cell wall synth inhib, inhibs cell walls early, used for UTIs

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34
Q

Erythromycin

A

Macrolide, static, 50s Inhib in one place, used for Mycoplasma pneumo and Legionella (STDs, gm+cocci, Neisseria, penicillin allergic peeps)
Adverse: cholestatic hepatitis, epigastr distress, CYP inhib, all kinds of GI motility

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35
Q

Clarithromycin

A

Macrolide, static, 50s Inhib in one place, used for Mycoplasma pneumo and Legionella (STDs, gm+cocci, Neisseria, penicillin allergic peeps)
Adverse: acute psychosis

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36
Q

Azithromycin

A

Macrolide, static, 50s Inhib in one place, used for Mycoplasma pneumo and Legionella (STDs, gm+cocci, Neisseria, penicillin allergic peeps), tissue conc is high so don’t have to give as long

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37
Q

Telithromycin

A

Ketolide, static, binds 50s in two places, only approved for community acquired pneumo
Adverse: acute hepatic failure don’t give to pts with Myasthenia gravis

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38
Q

Clindamycin

A

Lincosamide, static, 50s inhib, gm+, community MRSA, highly active against B. fragilis
Adverse: diarrhea and pseudomembranous colitis

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39
Q

Quinupristin/dalfoprisitn

A

Streptogramins, combo, bind at 50s diff places, only gm + and usually only when not responsive to other drugs (VRE faecium only and maybe MRSA?)
Adverse: venous issues at infusion site, arthralgia, myalgia, nausea, vomit, diarrhea

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40
Q

Linezolid

A

Oxazolidinone, 50s inhib, gm+, VRE (both) and MRSA
Adverse: myelosuppresion, thrombocytopenia and anemia if given for more than 28 days, nonspecific MOAI (contra for antidepressants)

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41
Q

Chloramphenicol

A

Nitrobenzene, 50s inhib, static, only serious infs not treated by others, usually meningitis, used a lot in poor countries cuz it’s cheap
Adverse: Aplastic Anermia (not reversible or dose dependent) can occur weeks to months after treatment, Blood dyscrasia (dose dependent and reversible) during active treatment, Gray baby syndrome (babies can’t glucorronylate them) they die

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42
Q

Tetracycline

A

Tetracycline, 30s inhib, static, Rickettsiae, Chlamydiae, Mycoplasma, H. pylori, Plasmodia, amebae
Adverse: hypersensitive, GI, photoxicity (use sunscreen), high doses cause hepatic dysfunct (especially preggers), teeth discoloration in kids

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43
Q

Minocycline

A

Tetracycline, 30s inhib, static, Rickettsiae, Chlamydiae, Mycoplasma, H. pylori, Plasmodia, amebae
Adverse: hypersensitive, GI, photoxicity (use sunscreen), high doses cause hepatic dysfunct (especially preggers), teeth discoloration in kids, vertigo and dizziness, skin hyperpigmentation

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44
Q

Doxycycline

A

Tetracycline, antimalaria, 30s inhib, static, Rickettsiae, Chlamydiae, Mycoplasma, H. pylori, Plasmodia, amebae
Adverse: hypersensitive, GI, photoxicity (use sunscreen), high doses cause hepatic dysfunct (especially preggers), teeth discoloration in kids

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45
Q

Tigecycline

A

Glycylcyline, binds 30s,static, MRSA, VRE, penicillin resistant S. pneumonia, Acinetobacter resistant to carbapenems, ESBL producing Enterobacteriacase
Effluxed only by Pseudomonas
Adverse: tons of nausea and vomiting

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46
Q

Gentamicin

A

Aminoglycoside, bind 30s, need O2, Severe gram- rod infs, can use with beta lactams
Bacteria metabolically innactivate
Adverse: Ototox, Nephrotox, Neuromuscular blockade (if diaphragm you die)

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47
Q

Tobramycin

A

Aminoglycoside, bind 30s, need O2, Severe gram- rod infs, can use with beta lactams
Bacteria metabolically innactivate
Adverse: Ototox, Nephrotox, Neuromuscular blockade (if diaphragm you die)

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48
Q

Amikacin

A

Aminoglycoside, bind 30s, need O2, Severe gram- rod infs, can use with beta lactams
Bacteria metabolically innactivate
Adverse: Ototox, Nephrotox, Neuromuscular blockade (if diaphragm you die)

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49
Q

Kanamycin

A

Aminoglycoside, bind 30s, need O2, Severe gram- rod infs, can use with beta lactams
Bacteria metabolically innactivate
Adverse: Ototox, Nephrotox, Neuromuscular blockade (if diaphragm you die)

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50
Q

Streptomycin

A

Aminoglycoside, TB drug,bind 30s, need O2, Severe gram- rod infs, can use with beta lactams
Bacteria metabolically innactivate
Adverse: Ototox, Nephrotox, Neuromuscular blockade (if diaphragm you die)

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51
Q

Neomycin

A

Aminoglycoside, bind 30s, need O2, Severe gram- rod infs, can use with beta lactams
Bacteria metabolically innactivate
Adverse: Ototox, Nephrotox, Neuromuscular blockade (if diaphragm you die)

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52
Q

Ciprofloxacin

A

Fluoroquinolones, binds and inhibs DNA gyrase (gm-) and topoisomerase IV (gm+), Gram- rods of urinary and GI tracts (including pseudomonas), Neisseria and some gram+, Levoflox and Moxiflox good with respiratory infs
Adverse: GI, Rash, CNS (headache, vertigo, etc), damage childrens cartilage, tendon rupture

53
Q

Levofloxacin

A

Fluoroquinolones, binds and inhibs DNA gyrase (gm-) and topoisomerase IV (gm+), Gram- rods of urinary and GI tracts (including pseudomonas), Neisseria and some gram+, Levoflox and Moxiflox good with respiratory infs
Adverse: GI, Rash, CNS (headache, vertigo, etc), damage childrens cartilage, tendon rupture

54
Q

Gatifloxacin

A

Fluoroquinolones, binds and inhibs DNA gyrase (gm-) and topoisomerase IV (gm+), Gram- rods of urinary and GI tracts (including pseudomonas), Neisseria and some gram+, Levoflox and Moxiflox good with respiratory infs
Adverse: GI, Rash, CNS (headache, vertigo, etc), damage childrens cartilage, tendon rupture

55
Q

Moxifloxacin

A

Fluoroquinolones, binds and inhibs DNA gyrase (gm-) and topoisomerase IV (gm+), Gram- rods of urinary and GI tracts (including pseudomonas), Neisseria and some gram+, Levoflox and Moxiflox good with respiratory infs
Adverse: GI, Rash, CNS (headache, vertigo, etc), damage childrens cartilage, tendon rupture

56
Q

Rifampin

A

Rifamycin, TB drug, inhibs DNA dep RNA polym, monotherapy for N. meningitidis but combo for everything else (quick resistance)
Adverse: minor hepatox, CYP inducer, orange body fluids (not hazardous)

57
Q

Rifabutin

A

Rifamycin, TB drug, inhibs DNA dep RNA polym, monotherapy for N. meningitidis but combo for everything else (quick resistance)
Adverse: minor hepatox, CYP inducer, orange body fluids (not hazardous)

58
Q

Sulfisoxazole

A

Sulfonamide, PABA analog so slowly depletes folate, static, Uncomp UTIs and nocardiosis
Adverse: Skin rash (possible Steven Johnson), drug fever, blood dyscrasia (rare), eosinophilia and other hypersensitivity, crystalluria (not really anymore), hepatitis possible, kernicterus in newborns cuz displaces bilirubin

59
Q

Sulfamethoxazole

A

Sulfonamide, PABA analog so slowly depletes folate, static, Uncomp UTIs and nocardiosis
Adverse: Skin rash (possible Steven Johnson), drug fever, blood dyscrasia (rare), eosinophilia and other hypersensitivity, crystalluria (not really anymore), hepatitis possible, kernicterus in newborns cuz displaces bilirubin

60
Q

Sulfalazine

A

Sulfonamide, PABA analog so slowly depletes folate, static, used for ulcerative colitis
Adverse: Skin rash (possible Steven Johnson), drug fever, blood dyscrasia (rare), eosinophilia and other hypersensitivity, crystalluria (not really anymore), hepatitis possible, kernicterus in newborns cuz displaces bilirubin

61
Q

Silver sulfadiazine

A

Sulfonamide, used as infections prophylaxis for burns

62
Q

Trimethoprim

A

Bact folic acid reductase inhib, folate can’t be recycled, static, mono only for simple UTI
Adverse: can interfere with folate metab in malnourished ppl (megaloblastic anemia, leukopenia and granulocytopenia)

63
Q

Trimethoprim/sulfmethoxazole

A

Sulfonamide/Reductase combo, TMP/SMX, used for bronchitis, otitis media, PCP (pneumo)

64
Q

Nitrofurantoin

A

UTIs, Unknown MOA, rapidly excreted by kidney, Adverse: GI and headache, acute allergic rxn (chills, cough, pulmonary infultrates), chronic allergy after 6mos of treatment (pulmonary fibrosis)

65
Q

Fosfomycin

A

UTIs, Inhibs enolpyruvyl transferase (cell wall inhib), used for uncomp acute UTI in ladies (E. coli and E faecalis sensitive)

66
Q

Methanamine

A

UTIs, makes formaldehyde in acidic urine, can’t use if urinating frequently

67
Q

Daptomycin

A

Lipopeptide, alters membrane permeability, MOA unknown, disrupts gm+ membrane potential, kills VRSA and VRE, active against biofilms, growing or resting bact

68
Q

Colisitn

A

Polymixin, alters membrane permeability, Interupt cell membranes of gm- aerobic bacilli, last resort drug, Adverse: very nephrotoxic

69
Q

Polymixin B and E

A

Polymixin, alters membrane permeability, Interupt cell membranes of gm- aerobic bacilli, last resort drug, Adverse: very nephrotoxic

70
Q

Colistimethate

A

Polymixin, alters membrane permeability

71
Q

Metronidazole

A

Antiprotozoa, MOA unknownish, may be free radical, used against protozoa and C diff, H. pylori, B fragilis, Adverse: headache and metallic taste, can cause disulfuram like if used with EtOH

72
Q

Spectinomycin

A

Alternate to penicillin/cephs for treatment of N gonorrhea only

73
Q

Fidaxomicin

A

similar to vanc, used for C diff associated diarrhea

74
Q

Isoniazid

A

TB drug, Primary TB drug, inhibs mycolic acid synth, drug must be activated by catalase/peroxidase (mutation leads to resistance), eliminated via acetylation, Adverse: peripheral neuritis (can be avoided), hepatoxicity which increases with age (after 35 may be unusable), all liver enzymes are increased X3

75
Q

Pyrazinamide

A

TB drug, MOA not really known, Adverse: dose-related hepatoxicity, hyperuricemia (may induce gout)

76
Q

Ethambutol

A

TB drug, MOA unknown, Adverse: uni or bilateral ocular toxicity, dose related and reversible, may precipitate gout, don’t use in kids

77
Q

Amphotericin B

A

Antifungal, polyene, used for serious systemic fungal infections, IV admin
Adverse: Hypersensitive, fever chills headache and GI (can go away), nephrotoxic (doesn’t go away)

78
Q

Nystatin

A

Antifungal, polyene, used for localized fungal infs only (like thrush), very hepatoxic

79
Q

Ketoconazole

A

Antifungal, 1st gen azol, inhibs a fungal P450, broad antifungal activity, needs acidic stomach if used PO
Adverse: hepatoxic, anaphylaxis, potent CYP3A4 inhib, can lower testosterone and ACTH

80
Q

Itraconazole

A

Antifungal, 2nd gen Azole, broad fungal coverage

Adverse: potent CYP3A4 inhib

81
Q

Fluconazole

A

Antifungal, 2nd gen Azole, PO available everywhere

Adverse: potent CYP3A4/2C9 inhib

82
Q

Voraconazole

A

Antifungal, 3rd gen Azole, used mainly for invasive fungal infs
Adverse: moderate CYP(several) inhib

83
Q

Terbinafine

A

Antifungal, allylamine, ergot inhib, use with other antifungals (azols) for broader, deeper coverage
Adverse: minor hepatoxic

84
Q

Capsofungin

A

Antifungal, Echinocandin, very expensive, invasive disease or when not responsive to other therapies

85
Q

Anidulafungin

A

Antifungal, Echinocandin, very expensive, invasive disease or when not responsive to other therapies

86
Q

Micafungin

A

Antifungal, Echinocandin, very expensive, invasive disease or when not responsive to other therapies

87
Q

Flucytosine

A

Antifungal, only active in fungal cells, synergistic with ampho (used alone resistance develops quickly), PO, excreted in urine
Adverse: Serious bone marrow suppresion, GI, rash, hepatic dysfunction

88
Q

Amantadine

A

Anti-Flu A, blocks uncoating

Adverse: confusion, hallucination, seizure, coma

89
Q

Rimantidine

A

Anti-Flu A, blocks uncoating

Adverse: some CNS, less than amantadine

90
Q

Oseltamivir

A

Anti-Flu, neuraminidase inhib, PO, some resistance, active against A and B
Adverse: self injury and delirium in kids has been reported

91
Q

Zanamivir

A

Anti-Flu, neuraminidase inhib, inhaled, not really any resistances, effective against A and B
Adverse: bronchospasm (watch in asthmatics)

92
Q

Acyclovir

A

Antiviral, nonHIV, IV, used for HS1/2 and VZV

Adverse: headache and GI, renal dysfunction due to crystals

93
Q

Valacyclovir

A

Antiviral, HSV1/2 VZV, PO

94
Q

Ganciclovir

A

Antiviral, CMV

95
Q

Valaganciclovir

A

Antiviral, CMV, proganciclovir

96
Q

Famciclovir

A

Antiviral, HSV1/2 VZV, PO

97
Q

Foscarnet

A

Antiviral, nonHIV, used to treat resistant CMV, HSV or VZV

Adverse: renal dysfunction, headache

98
Q

Ribivarin

A

Antiviral, nonHIV, RSV, parainflu, adeno

99
Q

Boceprevir

A

HCV, Antiviral, nonHIV, serine protease inib used with INF-alpa and ribavirin

100
Q

Telaprevir

A

HCV, Antiviral, nonHIV, serine protease inib used with INF-alpa and ribavirin

101
Q

Zidovudine

A

AntiHIV, nRTIs, mess up HIV RT

Adverse: lactic acidosis, hepatic steatosis, peripheral neuropathy, myopathy, lipoatrophy

102
Q

Didanosine

A

AntiHIV, nRTIs, mess up HIV RT

Adverse: lactic acidosis, hepatic steatosis, peripheral neuropathy, myopathy, lipoatrophy

103
Q

Lamivudine

A

AntiHIV, nRTIs, mess up HIV RT

Adverse: lactic acidosis, hepatic steatosis, peripheral neuropathy, myopathy, lipoatrophy

104
Q

Emtricitabine

A

AntiHIV, nRTIs, fewer side effects than others, mess up HIV RT
Adverse: lactic acidosis, hepatic steatosis, peripheral neuropathy, myopathy, lipoatrophy

105
Q

Tenofovir

A

AntiHIV, nRTIs, fewer side effects than others, mess up HIV RT
Adverse: lactic acidosis, hepatic steatosis, peripheral neuropathy, myopathy, lipoatrophy

106
Q

Efavirenz

A

AntiHIV, nnRTIs, only active against HIV1

Adverse: rash, CNS probs, teratogenic (don’t give to preggers)

107
Q

Nevirapine

A

AntiHIV, nnRTIs, only active against HIV1

Adverse: rash

108
Q

Atazanavir

A

AntiHIV, Protease Inhibitor, stop viral maturation

Adverse: GI, increased liver enzymes, buffalo hump, hyperlipidemia, type II diabetes, bleeding in hemopheliacs

109
Q

Darunavir

A

AntiHIV, Protease Inhibitor, stop viral maturation

Adverse: GI, increased liver enzymes, buffalo hump, hyperlipidemia, type II diabetes, bleeding in hemopheliacs

110
Q

Fosamprenavir

A

AntiHIV, Protease Inhibitor, stop viral maturation

Adverse: GI, increased liver enzymes, buffalo hump, hyperlipidemia, type II diabetes, bleeding in hemopheliacs

111
Q

Lopinavir

A

AntiHIV, Protease Inhibitor, stop viral maturation

Adverse: GI, increased liver enzymes, buffalo hump, hyperlipidemia, type II diabetes, bleeding in hemopheliacs

112
Q

Saquinavir

A

AntiHIV, Protease Inhibitor, stop viral maturation

Adverse: GI, increased liver enzymes, buffalo hump, hyperlipidemia, type II diabetes, bleeding in hemopheliacs

113
Q

Ritonavir

A

AntiHIV, PI booster, inhibs CYP so others aren’t metabolized as quickly

114
Q

Enfuvirtide

A

AntiHIV entry inhib, SubQ injection, blocks gp41 so HIV can’t bind to CD4

115
Q

Maraviroc

A

AntiHIV fusion inhib, binds CC5R so HIV can’t use that (but can use CXCR4)

116
Q

Raltegravir

A

AntiHIV integrase inhib, prevents HIV DNA from being put in host DNA

117
Q

Chloroquine

A

Antimalaria, stops bugs from taking over RBCs, number 1 drug for malaria
Adverse: reversible corneal damage or perm retinal damage (bull’s eye), can cause visual disturbances, hyperexcitibility, convulsions, heart block

118
Q

Mefloquine

A

Antimalaria, contraindicated if history of epilepsy, psychiatric disorder, arrhythmia, cardiac conduction issue

119
Q

Quinine

A

Antimalaria

Adverse: cinchonism (tinnitus, headache, nausea, visual disturbances, heart block

120
Q

Quinidine

A

Antimalaria

Adverse: cinchonism (tinnitus, headache, nausea, visual disturbances, heart block

121
Q

Primaquine

A

Antimalaria, only drug effective against liver hypnozoites (from P vivax/ovale)
Adverse: hemolytic anemia, don’t give to ppl with granulocytopenia or methemoglobinemia

122
Q

Malarone

A

Antimalaria, atovaquone and proguanil

A disrupts mitochond electric transport and P inhibs dihydrofolate reductase

123
Q

Coartem

A

Antimalaria, artemether and lumefantrine

124
Q

Artesunate

A

Antimalaria, only available from CDC

125
Q

Idoquinol

A

Antiprotozoa, amebiasis, use with metronidazole if serious

126
Q

Diloxanide furoate

A

Antiprotozoa, who the hell knows

127
Q

Pentamidine

A

Antiprotozoa, used for PCP pneumo with TMP/SMX

128
Q

Which plasmodia have latent liver infections?

A

P. vivax and ovale

129
Q

Life cycle of plasmodia?

A

Mosquito bites you, the sporozoites invade the liver extra fast and make an exoerthrocytic (or shiznot) that can bust and release merozoites into blood stream which go and invade RBCs and make shiznots which when they burst release pyrogenic factors
P. falciparum is the worst and most resistant organism

Med School (4 decks)

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