Pharm Block 2 Drugs Flashcards
Action of TCAs
Block reuptake NE and serotonin, Block muscarinic, and a1&a2 adrenergic receptors, interact w/ diff ion channels
Adverse Effects TCAs
Narrow therapeutic index, common agent used in suicide
TCA drugs
Amitriptyline, Clomipramine, Imipramine, Nortriptyline, Desipramine
SSRI Action
Block reuptake of serotonin
SSRI Adverse Effects
Well tolerated, GI, sexual dysfunction, CNS (nervousness, insomnia, dizziness)
SSRI drugs
Sertraline, Citalopram, Fluoxetine, Paroxetine
SNRI Drugs
Duloxetine
Venlafamine
Atypical Antidepressant drugs
Bupropion
Mirtazapine
MAOI drugs
Phenelzine, Tranylcypromine
Bipolar drugs
Lithium
Lamotrigine
Valproic Acid
Which bipolar drug is safe in pregnancy
Lamotrigine
Action of Trazodone and Vilazodone
Blocks presynaptic 5-HTI autoreceptors, weak inhibitor of SERT, blocks 5-HT2 receptors
Action of mirtazapine
Block presyn a2 autoreceptors, block postsyn 5-HT2 & 5-HT3 receptors, antihistamine
Atypical Antipsychotic drugs
Clozapine
Aripiprazole
Olanzapine
Quetiapine
Risperidone
Ziprasidone
Typical High Potency Antipsychotic drug
Haloperidol
Typical Low Potency Antipsychotic drug
Chlorpromazine
Advantages of Aripiprazole
Low incidence of weight gain, low risk of sedation, few antimuscarinic effects
Bezno action
Enhances binding of GABA to GABAA receptors to ↑ Cl- influx and ↓ neuronal excitability
Benzo adverse effects
Somnolence, Decrease in BP, respiratory depression, amnesia, impraired memory, cognitive function, paradoxical effects
Nonbenzo, Z drugs
Zaleplon (Sonata)
Zolpidem
(Ambien)
Eszopiclone
(Lunesta)
Barbituates
Phenobarbital & Pentobarbital
Barbituates Indication
Hypnotic, muscle relaxation (pheno)
Anesthesia (pento)
Barbituates Adverse Effects
Sedation, motor incoordination, resp. Depression, dependence, abuse, fatal CNS depression
Short Acting Benzos
Midazolam (Versed)
Triazolam (Halcion)
