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Semester 2 > Pharm Block 2 Drugs > Flashcards

Pharm Block 2 Drugs Flashcards

1
Q

Action of TCAs

A

Block reuptake NE and serotonin, Block muscarinic, and a1&a2 adrenergic receptors, interact w/ diff ion channels

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2
Q

Adverse Effects TCAs

A

Narrow therapeutic index, common agent used in suicide

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3
Q

TCA drugs

A

Amitriptyline, Clomipramine, Imipramine, Nortriptyline, Desipramine

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4
Q

SSRI Action

A

Block reuptake of serotonin

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5
Q

SSRI Adverse Effects

A

Well tolerated, GI, sexual dysfunction, CNS (nervousness, insomnia, dizziness)

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6
Q

SSRI drugs

A

Sertraline, Citalopram, Fluoxetine, Paroxetine

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7
Q

SNRI Drugs

A

Duloxetine

Venlafamine

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8
Q

Atypical Antidepressant drugs

A

Bupropion
Mirtazapine

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9
Q

MAOI drugs

A

Phenelzine, Tranylcypromine

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10
Q

Bipolar drugs

A

Lithium
Lamotrigine
Valproic Acid

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11
Q

Which bipolar drug is safe in pregnancy

A

Lamotrigine

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12
Q

Action of Trazodone and Vilazodone

A

Blocks presynaptic 5-HTI autoreceptors, weak inhibitor of SERT, blocks 5-HT2 receptors

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13
Q

Action of mirtazapine

A

Block presyn a2 autoreceptors, block postsyn 5-HT2 & 5-HT3 receptors, antihistamine

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14
Q

Atypical Antipsychotic drugs

A

Clozapine
Aripiprazole
Olanzapine
Quetiapine
Risperidone
Ziprasidone

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15
Q

Typical High Potency Antipsychotic drug

A

Haloperidol

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16
Q

Typical Low Potency Antipsychotic drug

A

Chlorpromazine

17
Q

Advantages of Aripiprazole

A

Low incidence of weight gain, low risk of sedation, few antimuscarinic effects

18
Q

Bezno action

A

Enhances binding of GABA to GABAA receptors to ↑ Cl- influx and ↓ neuronal excitability

19
Q

Benzo adverse effects

A

Somnolence, Decrease in BP, respiratory depression, amnesia, impraired memory, cognitive function, paradoxical effects

20
Q

Nonbenzo, Z drugs

A

Zaleplon (Sonata)
Zolpidem
(Ambien)
Eszopiclone
(Lunesta)

21
Q

Barbituates

A

Phenobarbital & Pentobarbital

22
Q

Barbituates Indication

A

Hypnotic, muscle relaxation (pheno)

Anesthesia (pento)

23
Q

Barbituates Adverse Effects

A

Sedation, motor incoordination, resp. Depression, dependence, abuse, fatal CNS depression

24
Q

Short Acting Benzos

A

Midazolam (Versed)
Triazolam (Halcion)

25
Q

Intermediate Benzos

A

Alprazolam (Xanax)
Lorazepam (Ativan)

26
Q

Long Acting Benzos

A

Clonazepam (Klonopin)
Diazepam (Valium)

27
Q

Side effect Clozapine

A

agranulocytosis

28
Q

Risperidone side effects

A

Higher incidence extrapyramidal symptoms (higher doses), prolonged QT interval, weight gain, increase prolactin

29
Q

Ziprasidone side effects

A

Prolongs QT interval

Semester 2 (6 decks)

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