PHARM BLESSINGS :) Flashcards
yaaaaaaaaaaaaaaaaaasssssssss
phhhhaaaaaaaarrrrrrrmmmmmm
ayyyyyyoooooooooooooooooo
Which 2 drugs, when prescribed together, can cause depression?
Ribavarin [Rebetol] + PEG-Interferon [Pegasys]
What percentage of people on Ribavarin [Rebetol] + PEG-Interferon [Pegasys] develop depression?
80%
(know this!)
What other side effects are seen with PEG-interferon [pegasys]
flu-like symptoms
(fever, chills, body aches)
can you use PEG-interferon [pegasys] for:
Hep B?
Hep C?
HIV?
B: yes
c: yes
HIV: no
can you use lamivudine [epivir] for:
hep b?
hep c?
hiv?
b: yes
c: no!
hiv: yes
which 2 meds are most commonly used with TB?
isoniazid and rifampin [rifadin]
By law, how should meds be given for TB?
direct observation therapy (DOT) to make sure they’re taking all their meds
what type of drug class can be used in TB?
mycobacterials
An infectious disease walks into a bar. The bartender says, “Oh, we don’t serve infectious diseases here.” What does the infectious disease say?
“well, you’re not a very good host.”
which drug can’t be used as sole therapy in TB?
why not?
rifampin [rifadin]
resistance builds quickly
what is the major side effect of isoniazid?
hepatitis
what is the most common side effect of rifampin [rifadin]
red/orange/yellow staining
which drug can cause s/e of anxiety, agitation, dizziness, and insomnia?
amantadine [symmetrel]
by how many days does tamiflu lessen the course of the flu?
less than one day
how is the drug zanamivir [relenza] administered
inhalation
what do you call a tv show where everyone compares who has the worst infectious disease?
deadliest catch
in which patients is zanamivir [relenza] contraindicated?
those with pulm diseases
is zanamivir [relenza] effective against both influenza A/B?
yes
does amantadine cover both influenza A/B?
only covers A
does tamiflu cover both influenza A and B?
yes
in the elderly, what do you check before prescribing influenza drugs?
eGFR
how do you treat any tick-borne disease?
doxycycline
what if a person comes in with a tick bite and is scared but doesn’t have a rash?
tell them to suck it up
but you can also give them a 1-time dose of doxycycline
is it necessary to test for lyme disease? why or why not?
not necessary - a lot of false positives. only order it if it will actually guide your tx
what tests diagnose lyme disease?
pcr and western blot
what is the most common symptom of lyme disease?
it turns you lime green
(*disclaimer: in case anyone is actually confused by this card, that’s not true at all)
when does a patient with lyme disease develop erythema migrans (bullseye rash over entire body)?
after 4-8 weeks
so AFTER they turn lime green
how many patients do not get a bullseye rash with lyme disease?
20%
at what egfr do you decrease acyclovir?
10-25
then again at < 10
can you give a CKD patient valcyclovir for shingles?
it’s not really effective because not magical like acyclovir, and also it’s a
prodrug
what is a major s/e of acyclovir and valcyclovir in high doses?
you turn lime green
just kidding, seizures
how do you treat malaria?
chloroquine sulfate [aralen]
what is the name of the *new* flu vaccine that is not on our drug table?
irrelevant
but in case it’s relevent it’s called trivalent
what do you call a female salmon?
salmonella
what is the most common malaria species?
falciparum
how do you treat head lice?
permethrin [nix]
is nitrofurantoin [macrobid] safe in pregnant women?
yes
what does pregnancy put you at a HUGE risk for?
someday having teenagers
no but for real, what does pregnancy put you at a huge risk for?
turning lime green
is nitrofurantoin [macrobid] metabolized and excreted quickly or slowly?
very quickly!!!!*
as quick as bunnies
does nitrofurantoin [macrobid] have lots or little of systemic absorption?
just a wee
so we’re talking about nitrofurantoin [macrobid] and using it in pregnancy but what do we use it to treat? (from the last module)
UTIs
(if you got this wrong: seriously, come on guys, it was less than a week ago)
(just kidding, just keep on being you)
during what phases of pregnancy should you not use nitrofurantoin [macrobid]
during 1st trimester
before giving birth
during the time that they turn lime green
in a CKD patient, do you have to adjust the dose of nitrofurantoin [macrobid]?
yes
are you SUPER sick of talking about nitrofurantoin [macrobid]?
YES ME TOO MOVING ON
what is a big side effect of nitrofurantoin [macrobid], especially those with pulmonary issues?
pulmonary fibrosis
a person comes back from camping, has diarrhea, is lime green, and has been drinking untreated water from the wild wild wilderness where the wild things are. what does he have?
traveler’s diarrhea
giardia
they don’t know
idk
how do you treat giardia?
metronidazole [flagyl]
what is praziquantel [bitricide] used to treat?
anti-helminth medication
treats schistosomyoniasisisisisiss
another one of those f*cking words i just can’t hang with
what is the s/e of metronidazole [flagyl] when you mix it with alcohol
disulfram-like effects
like PUKE PUKE PUKE
the infectious disease was kind of low on money, so what did she have to do for work to support her family?
she became a strepper
(I am sorry that you had to read this awful joke)
what does iodoquinol [yodoxin] treat?
intestinal amoeba infections
what can iodoquinol [yodoxin] interfere with?
iodine metabolism
what do you give if you want to prevent a person from going from latent TB to the real shiz?
isoniazid
what level will isoniazid mess up?
B6
these next ones are kind of loaded
but you’re pretty smart so I’m sure you’ll *catch* on……… just like an infectious disease!
also if you know the drug type, you pretty much know the MOA!
are my jokes getting worse?
yes
i know
i’ll work on it for next semester i promise
what is ribavarin [rebetol] for and what is its MOA?
anti Hep-C
inhibits protein synthesis
used in adjunct with PEG-interferon
what type of drug is lamivudine [epivir]
what is its MOA
and what is it for?
antiretroviral drug - NRTI
inhibits viral RNA to DNA transcription
for HIV, HBV
what type of drug is delaviridine [rescriptor]
what is its MOA
what is it for
antiretroviral: NNRTI
Non-Nucleoside Reverse Transcriptase Inhibitor
for HIV
what type of drug is darunivir [preziesta]
what’s the MOA
what is it for
antiretroviral: PI
binds to active site of HIV protease
HIV
what type of drug is enfuvirtide [fuzeon]
what is its MOA
what is it for
antiretroviral: fusion inhibitors
inhibits fusion of virus with host cell membrane
HIV
what type of drug is maraviroc [selzentry]
what is its MOA
what is it for
antiretroviral: CCR5 inhibitor
binds to CCR5 to inhibit HIV attachment
what type of drug is raltegravir [insentress]
antiretroviral: integrase inhibitor
inhibits HIV integrase to prevent viral DNA insertion
HIV
what type of drug is lamivudine [epivir]
what’s the MOA
what’s it for
Anti-hep B drug
inhibits reverse transcriptase
HBV, HIV
PEGylated-interferon alpha A2 [pegasys]
Antihepatitis B or C drug
it like stops everything
HBV, HCV
what type of drug is Ribavirin [Rebetron]
what does it treat
antihepatitis C drug
hcv, rsv
used with PEG-Interferon
there are 2 more antiviral drugs
i’m not doing them
there’s like a 0.5% chance we’ll even be tested on them
keep calm
pharm on
by the way, are you still listening to matchbox 20 from slide one?
regardless of whether you say yes or no,
good for you
