PHARM BLESSINGS :) Flashcards by Paige LaPointe

yaaaaaaaaaaaaaaaaaasssssssss

phhhhaaaaaaaarrrrrrrmmmmmm

ayyyyyyoooooooooooooooooo

https://www.youtube.com/watch?v=S5zttEPcCuQ

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Which 2 drugs, when prescribed together, can cause depression?

Ribavarin [Rebetol] + PEG-Interferon [Pegasys]

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What percentage of people on Ribavarin [Rebetol] + PEG-Interferon [Pegasys] develop depression?

80%

(know this!)

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What other side effects are seen with PEG-interferon [pegasys]

flu-like symptoms

(fever, chills, body aches)

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can you use PEG-interferon [pegasys] for:

Hep B?

Hep C?

HIV?

B: yes

c: yes

HIV: no

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can you use lamivudine [epivir] for:

hep b?

hep c?

hiv?

b: yes
c: no!
hiv: yes

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which 2 meds are most commonly used with TB?

isoniazid and rifampin [rifadin]

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By law, how should meds be given for TB?

direct observation therapy (DOT) to make sure they’re taking all their meds

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what type of drug class can be used in TB?

mycobacterials

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An infectious disease walks into a bar. The bartender says, “Oh, we don’t serve infectious diseases here.” What does the infectious disease say?

“well, you’re not a very good host.”

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which drug can’t be used as sole therapy in TB?

why not?

rifampin [rifadin]

resistance builds quickly

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what is the major side effect of isoniazid?

hepatitis

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what is the most common side effect of rifampin [rifadin]

red/orange/yellow staining

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which drug can cause s/e of anxiety, agitation, dizziness, and insomnia?

amantadine [symmetrel]

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by how many days does tamiflu lessen the course of the flu?

less than one day

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how is the drug zanamivir [relenza] administered

inhalation

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what do you call a tv show where everyone compares who has the worst infectious disease?

deadliest catch

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in which patients is zanamivir [relenza] contraindicated?

those with pulm diseases

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is zanamivir [relenza] effective against both influenza A/B?

yes

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does amantadine cover both influenza A/B?

only covers A

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does tamiflu cover both influenza A and B?

yes

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in the elderly, what do you check before prescribing influenza drugs?

eGFR

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how do you treat any tick-borne disease?

doxycycline

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what if a person comes in with a tick bite and is scared but doesn’t have a rash?

tell them to suck it up
but you can also give them a 1-time dose of doxycycline

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is it necessary to test for lyme disease? why or why not?

not necessary - a lot of false positives. only order it if it will actually guide your tx

what tests diagnose lyme disease?

pcr and western blot

what is the most common symptom of lyme disease?

it turns you lime green _{(*disclaimer: in case anyone is actually confused by this card, that's not true at all)}

when does a patient with lyme disease develop erythema migrans (bullseye rash over entire body)?

after 4-8 weeks so AFTER they turn lime green

how many patients do **not** get a bullseye rash with lyme disease?

20%

at what egfr do you decrease acyclovir?

10-25 then again at \< 10

can you give a CKD patient valcyclovir for shingles?

it's not really effective because not magical like acyclovir, and also it's a ## Footnote **_prodrug_**

what is a major s/e of acyclovir and valcyclovir in high doses?

you turn lime green just kidding, seizures

how do you treat malaria?

chloroquine sulfate [aralen]

what is the name of the \*new\* flu vaccine that is not on our drug table?

irrelevant but in case it's relevent it's called **trivalent**

what do you call a female salmon?

salmonella

what is the most common malaria species?

falciparum

how do you treat head lice?

permethrin [nix]

is nitrofurantoin [macrobid] safe in pregnant women?

yes

what does pregnancy put you at a HUGE risk for?

someday having teenagers

no but for real, what does pregnancy put you at a huge risk for?

turning lime green

is nitrofurantoin [macrobid] metabolized and excreted quickly or slowly?

very quickly!!!!\* as quick as bunnies

does nitrofurantoin [macrobid] have lots or little of systemic absorption?

just a wee

so we're talking about nitrofurantoin [macrobid] and using it in pregnancy but what do we use it to treat? (from the last module)

UTIs (if you got this wrong: seriously, come on guys, it was less than a week ago) (just kidding, just keep on being you)

during what phases of pregnancy should you not use nitrofurantoin [macrobid]

during 1st trimester before giving birth during the time that they turn lime green

in a CKD patient, do you have to adjust the dose of nitrofurantoin [macrobid]?

yes

are you SUPER sick of talking about nitrofurantoin [macrobid]?

YES ME TOO MOVING ON

what is a big side effect of nitrofurantoin [macrobid], especially those with pulmonary issues?

pulmonary fibrosis

a person comes back from camping, has diarrhea, is lime green, and has been drinking untreated water from the wild wild wilderness where the wild things are. what does he have?

traveler's diarrhea giardia they don't know idk

how do you treat giardia?

metronidazole [flagyl]

what is praziquantel [bitricide] used to treat?

anti-helminth medication treats schistosomyoniasisisisisiss another one of those f\*cking words i just can't hang with

what is the s/e of metronidazole [flagyl] when you mix it with alcohol

disulfram-like effects like PUKE PUKE PUKE

the infectious disease was kind of low on money, so what did she have to do for work to support her family?

she became a strepper (I am sorry that you had to read this awful joke)

what does iodoquinol [yodoxin] treat?

intestinal amoeba infections

what can iodoquinol [yodoxin] interfere with?

iodine metabolism

what do you give if you want to prevent a person from going from latent TB to the real shiz?

isoniazid

what level will isoniazid mess up?

these next ones are kind of loaded

but you're pretty smart so I'm sure you'll \*catch\* on......... just like an infectious disease! also if you know the drug type, you pretty much know the MOA!

are my jokes getting worse?

yes i know i'll work on it for next semester i promise

what is ribavarin [rebetol] for and what is its MOA?

anti Hep-C inhibits protein synthesis **used in adjunct with PEG-interferon**

what type of drug is lamivudine [epivir] what is its MOA and what is it for?

antiretroviral drug - NRTI inhibits viral RNA to DNA transcription for HIV, HBV

what type of drug is delaviridine [rescriptor] what is its MOA what is it for

antiretroviral: NNRTI Non-Nucleoside Reverse Transcriptase Inhibitor for HIV

what type of drug is darunivir [preziesta] what's the MOA what is it for

antiretroviral: PI binds to active site of HIV protease HIV

what type of drug is enfuvirtide [fuzeon] what is its MOA what is it for

antiretroviral: fusion inhibitors inhibits fusion of virus with host cell membrane HIV

what type of drug is maraviroc [selzentry] what is its MOA what is it for

antiretroviral: CCR5 inhibitor binds to CCR5 to inhibit HIV attachment

what type of drug is raltegravir [insentress]

antiretroviral: integrase inhibitor inhibits HIV integrase to prevent viral DNA insertion HIV

what type of drug is lamivudine [epivir] what's the MOA what's it for

Anti-hep B drug inhibits reverse transcriptase HBV, HIV

PEGylated-interferon alpha A2 [pegasys]

Antihepatitis B or C drug it like stops everything HBV, HCV

what type of drug is Ribavirin [Rebetron] what does it treat

antihepatitis C drug hcv, rsv **used with PEG-Interferon**

there are 2 more antiviral drugs i'm not doing them there's like a 0.5% chance we'll even be tested on them

keep calm pharm on

by the way, are you still listening to matchbox 20 from slide one?

regardless of whether you say yes or no, good for you