Pharm b lactams and cell wall synthesis inhibitors

Question 1

almost exclusively used to treat mycobacterium tuberculosis resistant to first line agents

Answer 1

cycloserine

Question 2

Structural analog of D-alanine and thus inhibits its incorporation into the peptidoglycan pentapeptide by inhibiting alanine racemase

Answer 2

cycloserine

Question 3

Approved for single use 3g dose for uncomplicated UTI in women, safe for use during pregnancy

Answer 3

fosfomycin

Question 4

: inhibits cell wall synthesis at very early stage by inhibiting enolpyruvate transferase thus preventing the formation of UDP–N acetylmuramic acid, the precursor of N-acetylmuramic acid, and thus decreasing the integrity of the bacterial cell wall

Answer 4

fosfomycin

Question 5

Indicated for surface lesions of the skins, in wounds, or mucous membranes

Answer 5

bacitracin

Question 6

Ototoxicity and Nephrotoxicity are both increased when given with other drugs (ex: aminoglycosides) that also produce these side effects

Answer 6

vancomycin

Question 7

Binds to the D-Ala-D-Ala terminus preventing peptidoglycan elongation and cross-linking

Answer 7

vancomycin

Question 8

Administered with cilastatin to inhibit dehydropeptidase

Answer 8

imipenem

Question 9

dose-related CNS toxicity with headaches, tremors acute psychosis and convulsions

Answer 9

Cycloserine

Question 10

inhibits cell wall formation by interfering with the lipid carrier that transfers peptidoglycan subunits to the growing cell wall

Answer 10

bacitracin

Question 11

Resistance to vancomycin comes about through

Answer 11

The terminal D-ala becomes D-lactate

Question 12

Excessive doses in patients with renal failure  seizures

Answer 12

Imipenem

Question 13

Can be given to penicillin-allergic patients without reaction
Can treat pneumonia, meningitis and sepsis caused by Gram-negative pathogens

Answer 13

Aztreonam