Pharm - Autonomic Sympathetic drugs 2

Question 1

Clonidine

Answer 1

Sketchy: 2-claw weaponMOA:Alpha-2 agonist (sympatholytic)Effects:Inhibition of sympathetic tone - reduced BPUses:Hypertensive emergencyADHD (distracting mirror)Tourette (puppet)Adverse Effects:CNS depressionBradycardiaHypotensionRespiratory depressionMiosis

Question 2

Alpha-Methyldopa

Answer 2

Sketchy: alpha-shaped dope ropeMOA:Alpha-2 agonist (sympatholytic)Effects:Inhibition of sympathetic tone - reduced BPUses:Gestational HTNAdverse effects:Direct Coombs + hemolysisSLE-like syndrome

Question 3

Phenoxybenzamine

Answer 3

Sketchy: irreversible phoenix tattooMOA:Non-selective alpha blocker (irreversible)Uses:-Pheochromocytoma (use pre-operatively)-Cocaine toxicityAdverse Effects:Orthostatic hypotensionReflex tachycardia

Question 4

Phentolamine

Answer 4

Sketchy: phantomMOA:Non-selective alpha blocker (reversible)Uses:-Hypertensive crisis caused by tyramine toxicity with MAO inhibitors Adverse effects:Orthostatic hypotensionReflex tachycardia

Question 5

(“-osin”) Prazosin, Terazosin, Doxazosin, Tamsulosin

Answer 5

Sketchy: Opera SINgerMOA:Alpha-1 antagonistEffects:VasodilationRelaxation of smooth muscle of urethra and prostateUses:Urinary sx of BPHPTSD (Prazosin)HypertensionAdverse effects:1st dose orthostatic hypotension, dizziness, HA

Question 6

Mirtazapine

Answer 6

Sketchy: Mirth and Misery masksMOA:Alpha-2 antagonist (enhances the release of NE and 5HT)Uses:DepressionAdverse effects:SedationIncreased serum cholesterolIncreased appetite

Question 7

Atenolol, Betaxolol, Esmolol, Acebutolol, Metoprolol

Answer 7

Sketchy: A-BEAM spotlight in Brahm’s LOLlabyMOA:Beta-1 selective antagonist (B1 selective go from A-M)Effects:Decreased HR and contractilityDecreased AV conductionDecreased cardiac outputUses:AnginaMISVT (metoprolol, esmolol)HTN Heart failureAdverse effects:BradycardiaHeart block

Question 8

Carvedilol

Answer 8

Sketchy: carved candleholderMOA:Non-selective beta antagonist with additional alpha-1 blocking effects (non-selective antagonists have modified -olol suffix)Uses:Chronic heart failure+ all B1-blocker actions

Question 9

Labetalol

Answer 9

Sketchy: alpha and beta organ with extinguished candleMOA:Non-selective beta antagonist with additional alpha-1 blocking effects (non-selective antagonists have modified -olol suffix)Uses:-All B1-blocker actions-Hypertensive emergency (due to a1 antagonism - vasodilation)-HTN in pregnancy-Acute aortic dissection

Question 10

Timolol

Answer 10

Sketchy: draining of the muted beta-2 eyeball tubaMOA:Non-selective beta antagonist Uses:Glaucoma (via B2 antagonism)

Question 11

Acebutolol

Answer 11

Sketchy: agonizing plastic bugle in the audienceMOA:Selective beta-1 antagonist with partial agonist activity (part of A-BEAM)Not recommended in heart failure

Question 12

Pindolol

Answer 12

Sketchy: agonizing pin in the audienceMOA:Non-selective beta blocker with partial agonist activityNot recommended in heart failure