Pharm - Autonomic Sympathetic drugs 1 Flashcards
Albuterol, Salmeterol, Formoterol
Sketchy: “Roll” call sheet in hands of beta-2 tuba playerMOA:Direct sympathomimetic B2 > B1 agonistEffects:Bronchodilation (B2)Uses:Acute asthma or COPD
Dobutamine
Sketchy: “Just DO BUgling” shirtMOA:Direct sympathomimetic B1 > B2 agonistEffects:Increased HR, contractility, and cardiac output (B1)Decreased SVR due to vasodilation (B2)Uses:Heart failureCardiac stress testing
Epinephrine
Sketchy: epic kiss between alpha and beta campersMOA:Direct sympathomimetic B > a agonist Effects:-At low doses - beta effects predominate (bronchidilation, vasodilation/decreased SVR, elevated HR and contractility)-At high doses - alpha effects predominate (vasoconstriction)Uses:Anaphylaxis (a1 counteracts vasodilation, B1 increased blood flow to tissues, B2 opens airways)Asthma (B2)Open angle glaucoma
Isoproterenol
Sketchy: iso-pro-tunnel between beta-1 and beta-2 tentsMOA:Direct sympathomimetic B1 = B2 agonistEffects:Elevated HR and contractility (B1)Vasodilation and decreased SVR (B2)Uses:Electrophysiologic evaluation of tachyarrhythmias (may worsen ischemia)
Midodrine
Sketchy: NONEMOA:Direct sympathomimetic a1 agonistUses:Autonomic insufficiency and postural hypotension
Norepinephrine
Sketchy: north compass on alpha camp side by blowing B1 bugle MOA:Direct sympathomimetic a1 > a2 > B1 Effects:Increased SVR (a1)Increased HR (B1)Uses:Hypotension (a1 vasoconstriction)Septic shock
Phenylephrine
Sketchy: flannel friendsMOA:Direct sympathomimetic a1 > a2 agonistEffects:VasoconstrictionMydriasisUses:HypotensionOcular procedures (mydriasis)Rhinitis (nasal decongestant due to a1 vasoconstriction)
Terbutaline
Sketchy: “do not disTURB” sign near pregnant ladyMOA:Direct sympathomimetic B2 agonistEffects:Relaxation of uterine contractionsUses:Decrease contractions during preterm labor
Ritodrine
Sketchy: “I DREAM of band camp” shirt on pregnant ladyMOA:Direct sympathomimetic B2 agonistEffects:Relaxation of uterine contractionsUses:Decrease contractions during preterm labor
Amphetamine
Sketchy: “A fried of mine” shirt releasing catfish from vesicleMOA:Indirect sympathomimetic Catecholamine reuptake inhibitor, releases stored catecholaminesUses:NarcolepsyObesityADHD
Cocaine
Sketchy: hot cocoaMOA:Indirect sympathomimetic Inhibits NET and DAT, allowing catecholamines to remain in synapse Effects:-Peripheral NET inhibition leads to sympathetic stimulation (HTN, tachycardia, mydriasis)-Central DAT inhibition leads to increased dopamine in the CNS (arousal, addiction, seizures)Uses:Vasoconstriction and local anesthesiaAdverse effects:Never give beta blockers for acute cocaine intoxication - will lead to unopposed alpha activation and extreme HTN
Ephedrine
Sketchy: NONEMOA:Indirect sympathomimetic Releases stored catecholaminesUses:Nasal decongestionUrinary incontinenceHypotension
Metyrosine
Sketchy: “My tire!”MOA:Indirect sympathomimetic Prevents conversion of tyrosine to L-DOPA within the presynaptic nerve terminal
Atomoxetine
Sketchy: distracting HD TV with atom on itMOA:Indirect sympathomimeticNET inhibitorUses:ADHD
Reserpine
Sketchy: serpents blocking “V” matMOA:Inhibits VMAT (vesicular monamine transporter) so that catecholamines cannot be transported into secretory vesiclesUses:Huntington’s (degeneration of GABAergic neurons)
