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Pharma - Little bit of this little bit of that > Pharm - antiprotozoal > Flashcards

Pharm - antiprotozoal Flashcards

0
Q

Metronidazole side effects?

A

disulfiram-like effects and metallic taste

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1
Q

DOC for treating Amebiasis, Giardiasis and Trichomonas?

A

Metronidazole

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2
Q

Metronidazole mechanism of action?

A

not known

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3
Q

Toxoplasmosis treatment?

A

Pyrimethamine + sulfadiazine

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4
Q

Antimalarial drugs?

A

Chloroquines

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5
Q

what is cinchonism?

A

muscarinic and alpha adrenergic antagonism

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6
Q

Chloroquine moa?

A

results in conversion of toxic host Hgb by-products to non-toxic by-products

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7
Q

Chloroquine area of use?

A

Malaria - prophyaxis and to control recurrence. NOT curative

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8
Q

Chloroquine side effects?

A

IV infusion or single high dose(..30mg/kg) may be fatal

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9
Q

Primaquine area of use?

A

Malaria

  • terminal prophylaxis
  • radical cure
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10
Q

Primaquine adverse effects?

A
  • severe hypotension
  • intravascular hemolysis
  • do NOT use during first trimester
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11
Q

Quinine and quinidine general picture?

A
  • active against erythrocytic stage of malaria

- low therapeutic window + hypoglycemia & hypotension

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12
Q

Mefloquine target organism and side effects?

A

Chloroquine resistant strains of P. falciparum

- contraindicated in epileptics and mentally ill due to CNS involvement

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13
Q

Pyrimethamine moa?

A

inhibits dihydrofolate reductase in Plasmodia at lower concentrations than in mammalian cells.

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14
Q

Important group of antibiotics in chloroquine restistant Plasmodia?

A

sulfonamides

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15
Q

Amebiasis pathogen?

A

Entamoebae histolytica

16
Q

To cure amebiasis administer…

A

Metronidazole

17
Q

Metronidazole and amebiasis general picture?

A
  • curative against intestinal and hepatic amebiasis

- do NOT use during first trimester

18
Q

Leichmaniasis treatment?

A 
Stibogluconate sodium(Pentostam)
10-30 day treatment
19
Q

To treat Chagas disease(T. cruzi) give…

A

Nifurtimox

20
Q

African sleeping sickness DOC?

A

Suramin to cure and Eflornithine to “ressurect”

21
Q

Giardiasis DOC?

A

Metronidazole

22
Q

Toxoplasmosis DOCs?

A

Pyrimethamine and sulfadiazine

Pharma - Little bit of this little bit of that (10 decks)

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