Pharm - antihelminthic

Question 0

Most cestodes(tapeworms) and trematodes(flukes) can be cured with …….

Answer 0

Praziquantel - causing Calcium influx and subsequent paralysis of the organism.

Question 1

Most intestinal nematodes are cured with ……….

Answer 1

Mebendazole - lowered glucose and microtubular structure

Pyrantel pamoate - Nicotinic muscular antagonist causing spastic paralysis of the bug.

Question 2

Mebendazole and albendazole moa?

Answer 2

1 Inhibits glucose uptake
2 low glucose equals no low ATP = death and despair
3 binds to B-tubulin and inhibits polymerization and assembly of microtubules

Question 3

Pyrantel pamoate moa?

Answer 3

neuromuscular blockade and inhibition of AChE = paralysis

Question 4

Pyrantel pamoate taret organisms?

Answer 4

pinworm, roundworm and hookworm

wormy wormy woooOOOOoooormy

Question 5

Piperazine citrate moa and target organism?

Answer 5

blocks response to ACh ==> paralysis in ascaris

Question 6

Ivermectin moa?

Answer 6

interferes with invertebrate GABA gated Cl- channels = paralysis

Question 7

Ivermectin target organism

Answer 7

Lymphatic filariasis

Question 8

Iver kan kurerere elfantsyken?

Answer 8

Ivermectin DOC in curing infection with Lymphatic filariasis and subsequent elephantiasis