Pharm - Antiplatelet

Question 1

What are the 4 families of drugs that fall under anti-platelet drugs?

Answer 1

Inhibit Cox (synthesis of TXA2), ADP receptor blocker, 2b/3a blocker, PDE blockers

Question 2

MOA of Aspirin?

Answer 2

Cox inhibitor which leads to TXA2 reduction.

Question 3

Clinical use of Aspirin?

Answer 3

Prevention of MI and other vascular events

Question 4

What is the MOA for ADP receptor blockers?

Answer 4

Free Adenylyl cyclase from inhibition and increase cAMP levels which does not allow the 2b/3a receptor to be expressed.

Question 5

MOA for PDE blockers?

Answer 5

Inhibit cAMP depredation which leads to same result.

Question 6

MOA of 2b.3a blockers?

Answer 6

Does not allow the platelet to bind to fibrinogen to cause aggregation.

Question 7

Clinical indication for anti-platelet drugs?

Answer 7

Prevent thrombosis

Question 8

MOA for thrombolytic drugs?

Answer 8

Convert plasminogen to plasmin to cut that clot up.

Question 9

What are the three types of plasminogen activators?

Answer 9

Tissue type, urokinase in kidney, streptokinase from streptococci

Question 10

Clinical uses of thrombolytics? 4 things.

Answer 10

Acute thrombus, acute MI, PE, DVT

Question 11

How quickly do fibrinolytics need to be given?

Answer 11

Within 3 hours of event.

Question 12

2 adverse effects of fibrinolytics?

Answer 12

Bleeding and allergic reactions