Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neoplasia Block > PHARM: Anti-HIV drugs > Flashcards

PHARM: Anti-HIV drugs Flashcards

1
Q

What does p24 in ELISA indicate?

A

HIV (p24 is a capsule protein that incr viral load)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are two other sx in primary HIV syndrome

A

HAND: HIV assoc neurologic dysfxn
Seroconversion: HIV ab negative for first few months then converts to positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the four types of HIV therapy

A

Reverse Transcriptase Inhibs
Entry inhibs
Protease inhibs
Integrase inhibs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which type of HIV drug is involved in salvage therapy?

A

Entry inhibitors!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the 2 entry inhibitors?

A

Enfuvirtide and Maraviroc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which drugs end in “navir”?

A

Protease inhibitors!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which drugs end in “gravir”?

A

Integrase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which drug besides protease inhibs suppresses Cytochrome P450?

A

Colbicisat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What do NRTIs do?

A

Disrupt chain elongation (inhib DNA poly)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Main toxicity of NRTI?

A

Mitochondrial toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is Tenofovir?

A

only nucleotide RT inhib phosphorylated once

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What do entry inhibitors Enfuvirtide and Maraviroc do?

A

Enfuvirtide- changes gp40 (proteolytic hydrolysis met, not 450)
Maraviroc- CCR5 costim inhib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Integrase inhibs sxe

A

Steven johnsons

met by glucor not 450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

HAART tx?

A

need at least THREE drugs from at least 2 diff categories

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which drug should we use first in HAART, but what if pt has obesity/CV issues?

A

protease inhibs, unless CV issues then use NRTI (2) + NNRTI etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Whats an example of a combo of HAART to avoid?

A

avoid 2 NNRTIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

An ex of a sxe with a protease inhib

A

insulin resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which drug is v strong inhib of P450 so can use w PI to make it stronger?

A

ritonavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Adv to phenotype testing? Disadv?

A

Adv: direct, can do partial res
Disadv: cutoffs not standardized, less sensitive than geno, $$$

20
Q

What conversion rxn is inv in dTMP synth

A

DHF to THF via DHF reductase (produces deoxythymy, a DNA synth component)

21
Q

Hematochromatosis

A

Chronic excess of total body iron (eg issue with abs or frequent transfusions)

22
Q

Which defs cause microcytic vs megaloblastic anemia?

A

Microcytic-iron def

Megaloblastic-B12 and folate def

23
Q

What is pernicious anemia caused by?

A

defect in INTRINSIC FACTOR which helps with B12 absorption

24
Q

What to G-CSF and GM-CSF do?

A

tx, hematopo GFs which improve rbc count, stim granulocytes (neutros) and myleoid cells

25
Q

Why would renal failure cause anemia

A

kidneys produce EPO!

26
Q

What is epoeitin-alpha?

A

Recomb EPO for renal failure, acts on receptors on ery progens in bone marrow to stim rbc prod (receptor agonist)

27
Q

2 forms of EPO that have longer half lives?

A 
Darbepoeitin alpha (glycosylated form)
Methoxy.......beta
28
Q

EPO tox/complications?

A

HTN and thrombosis

29
Q

What do u treat with EPO?

A

chronic and end stage renal dis

30
Q

who gets iron def

A

women bc blood loss and vegetarians/malnourished

31
Q

iron supplements

A

ferrous sulfate gluconate and fumaarate

32
Q

IV iron

A

iron dextran, sodium ferric gluconate complex, iron sucrose

33
Q

Why cant iron be given in hemolytic anemia

A

iron stores elev in this

34
Q

in which anemia should iron NOT be given

A

hemolytic anemia

35
Q

which ppl shoudl have folate supp

A

pregnancy!

36
Q

If megaloblastic anemia, what should be ruled out before dx with folic acid def?

A

b12 def

37
Q

B12 is produced by gut bacteria and needs ___produced by ____ to absorb iron in the ____

A

IF, gastric parietal cells, intestine

38
Q

which def causes neuro issues

A

b12

39
Q

2 forms of b12 and which has longer half life

A

hydroxycobalamin

40
Q

what conversions does b12 do

A

homocystine AND methylmalonyl coa

41
Q

How is iron conv and abs by ints

A

iron abs as ferrous Fe2+ hem via DMT1 transporter in int.
stored as ferritin
when iron needed, ferrious iron transf across BL by ferroportin then oxidized to ferric Fe3 by ferroxidase
-ferric complexed with transferrin and transp to blood

42
Q

Tx of acute iron intox

A

DEFEROXAMINE (common in kdis)

43
Q

Tx of chronic iron intox

A

DEFERASIROX or above iron chelators

44
Q

what do b12 and folic acid help w

A

DNA SYNTH OF RBC

45
Q

Why is folic acid monoTx contraind in tx of pernicious anemia?

A

bc doesnt tx b12 neuro issues!

Neoplasia Block (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions