IID first 2 lectures (viral hemorrh fever, and opportunistic fungal infxns) Flashcards
What are the four virus families that can cauyse VHF (viral hemorrhagic fever?)
- Bunyaviruses,
- Flaviviruses,
- Arenavruses,
- Filoviruses
VHF characteristics, Sx, results, etc.
- zoonotic, animal/insect reservoirs
- intial sx: fever, lethary, myalgia, then progress to shock, sys failure, death (increased capillary perm/ imapired coag/ imparied cardiac fxn)
Example of Bunyavirus
crimean congo fever
example of flavivirus (2)
dengue
yellow fever
Examples of arenavirus (2)
lassa
LCMV
example of filovirus
ebola
Crimean Congo Fever reservoir region targe sx
ticks mostly (and small vert) middle east (and africa) targets liver and vasc endoth sx: usual VHF, limb pain (BUNYAVIRUS)
Dengue virus reservoir region sx test tx
aedes aegypti mosquito
India (+ other dev)
sx: general, hypotension, PETECHIAE, tachycardia, clammy extrem, incr vasc perm causes pleural effusion/ascites
Test with TOURNIQUET TEST: inflate BP cuff and check if petechiae
Tx: antypyretics (no NSAIDS bc guillen barre risk) etc
FLAVIVIRUS
Yellow fever virus
reservoir
region
sx
aedes mosquito (and monkeys)
Region: w africa, s america, was an outbreak in NOLA (tusom)
Sx: general
FLAVIVIRUS
Lassa reservoir region sx test tx
multimammate rat, its poop contaminates food W and Central Africa sx: VHF, 30% hemorr bleeding Test with LASV Ag rapid test Tx: ribavirin ok (biosafety lvl 4 with dengue) -can be nosocomial -LCMV, the other ARENAVIRUS is used as a research tool
Ebola virus Reservoir and trasmission region sx and timeline testing
mammals, then transmitted via bodily fluids
central to west africa (eg bats)
sx: general, sore throat, conjunctivitis, diarrhea, bleeding gums, high mortality, GI pain
Timeline: headache/fatigue/pain/mild fever (1 week), then severe high fever and vomiting blood, then bleeding/ brusing/ brain dmg, then loss of consciousness, seizures, multi organ, massive int bleeding, death
Test: RDT ,blood via fingerstick, prevent outbreaks
-survivor can carry virus esp in immunopriv sites (brain and eyes)
What 3 disease things can be caused by fungi?
Allergies
Mycotoxicoses
Mycoses (infections)–superficial, cut/subcut, sys
often in immunocompromised hosts
Most significant opportunistic fungal pathogen?
CANDIDA!
SYSTEMIC fungi infections list
candida albicans etc Cryptococcus neoformans Pneumocystitis jiroveci (aka P carinii) Aspergillus fumigatus and others ZYgomycetes/mucormycetes like rhizopus Histoplasma Blastomyces and coccidiodes (become opportunistic in IC indiv)
SUPERFICIAL fungal infections list
Candida
Malassezia
Trichophyton
Epidermophyton (lower 2 are dermatophytes)
Things that can cause OFPs
long term use of broad spectrum antibiotics (candida_
immunosuppressive drugs during trnasplants etc
radiation
loss of helper T cells due to AIDS
cancer, burns, IDs, neutropenia, diabetes etc
Which OFP can be dx with India ink to show CAPSULE?
Cryptococcosis (neoformans)
Which OFP has septate hyphae that branch at 45deg angles, and which has non-septated hyphae that branch at 90deg angles?
45- aspergillosis
90- mucormycosis/zygomycosis
which OFP should be treated with ampho+flucy?
cryptococcosis
which OFP is angioinvasive
Aspergillosis (fumigatus)
Which OFP is the AIDS defining illness?
PCP (peumocystis carinii penumonia) (P jiroveci)
Which OFP can cause cerebromeningeal infection?
Cryptococcosis
Which OFP is ONLY always a yeast
Cryptococcosis
Which OFP is the ONLY encapsulated fungal pathogen
Cryptococcosis
Common antimycotic for OFPs?
Amphotericin B! (affects erg in cell MEMBRANE)
Which OFP cannot be cultured?
PCP! use xray, broncial biopsy, serology for LDH lvl