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PANCE > Pharm > Flashcards

Pharm Flashcards

1
Q

HMG-CoA reductase inhibitors

  • aka
  • MOA
A
  • statins

- inhibits rate limiting step in hepatic cholesterol syntheses > inc LDL receptors os more LDL is removed from the blood

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2
Q

HMG-CoA reductase inhibitors

- lipid/lipoprotein effect

A
  • Dec LDL*
  • Dec TG
  • Inc HDL
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3
Q

HMG-CoA reductase inhibitors

- ADR

A
  • myopathy
  • transaminitis
  • rhabdo (esp when used with niacin or fibrates)
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4
Q

HMG-CoA reductase inhibitors

- best time to take

A

nighttime

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5
Q

Niacin

  • aka
  • lipid/lipoprotein effect
A
  • nicotinic acid
  • Dec LDL
  • Dec TG
  • Inc HDL*
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6
Q

Niacin

- ADR

A
  • Flushing
  • Hyperglycemia
  • Hyperuricemia
  • Hepatoxicity
  • GI discomfort
  • HA
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7
Q

Fibrates

- lipid/lipoprotein effect

A
  • Dec LDL
  • Dec TG*
  • Inc HDL
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8
Q

Fibrates

- names

A
  • gemfibrozil

- xxfibrate

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9
Q

Fibrates

- ADR

A
  • dyspepsia
  • gallstones
  • myopathy (esp with statins)
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10
Q

Bile Acid Sequestrants

- names

A
  • Cholestyramine
  • Colestipol
  • Colesevelam
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11
Q

Bile Acid Sequestrants

- lipid/lipoprotein effect

A
  • Dec LDL
  • Inc HDL
  • no change TG
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12
Q

Bile Acid Sequestrants

- MOA

A

binds to bile acids in intestine, blocking enterohepatic reabsorption of bile acides

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13
Q

Bile Acid Sequestrants

- ADR

A
  • GI discomfort
  • constipation
  • Dec absorption other drugs (Warfarin, digoxin, fat soluble vitamins)
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14
Q

Bile Acid Sequestrants

- what is it also used for besides lipid effects

A

pruritus associated with biliary obstruction

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15
Q

What is the only lipid therapy that is safe in pregnancy?

A

Bile Acid Sequestrants

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PANCE (14 decks)

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