Pharm Flashcards
Which antipsychotic drug treats the negative effects of schizophrenia?
Partial D2 receptor agonist
How do alpha 1 adrenoreceptors influence blood pressure?
constriction of vascular smooth muscle
Which type of drug reduces blood pressure by decreasing cardiac output but not TPR?
Calcium channel blockers
Use of statins causes a build up of what enzyme in cholesterol synthesis pathway?
HMG CoA
What type of drug would you administer for DVT?
Thrombolytic
What antihypertensive would you give to a man with hypertension, microalbuminuria and T1DM diagnosed 10 years ago?
ACE inhibitor
Man with Parkinson’s given L-DOPA and had nausea & vomiting. What drug would you give next ?
Carbidopa
What is the MOA of fluoroquinolones?
inhibit topoisomerase IV
Which anti-emetic could cause galactorrhea?
Metoclopramide (D2 receptor antagonist)
What does atropine prevent during general anesthesia?
increased bronchial secretions
Why does diazepam have a longer duration of action compared to other benzos?
it is broken down into active metabolites
What is the role of GABA transaminase?
breaks down GABA to L-glutatmate
A man is taking digoxin for AF, and presents to clinic with increased ventricular rate, what is the first biochemical test you should do?
K+
first line treatment for alzheimers
anticholinesterase
How does alcohol affect lipid and carbohydrate metabolism?
increases the NADH/NAD ratio
What type of rxn is alcohol –> acetaldehyde?
oxidation
Why is IV sodium bicarb given to treat aspirin overdose?
to increase urinary excretion of the drug by increasing plasma pH so drug is more ionised and excreted in kidneys
What antihypertensive drug acts directly on the adrenal gland?
renin inhibitors
Which antihypertensive should you not give to an asthmatic with hypertension?
beta blocker (block B2 mediated bronchodilation)
What receptor does alcohol act on to cause euphoria?
opioid receptor inhibiting GABAergic neurons in VTA which increase DA release to NAcc –> eurphoria
