Pharm

Question 1

Which antipsychotic drug treats the negative effects of schizophrenia?

Answer 1

Partial D2 receptor agonist

Question 2

How do alpha 1 adrenoreceptors influence blood pressure?

Answer 2

constriction of vascular smooth muscle

Question 3

Which type of drug reduces blood pressure by decreasing cardiac output but not TPR?

Answer 3

Calcium channel blockers

Question 4

Use of statins causes a build up of what enzyme in cholesterol synthesis pathway?

Answer 4

HMG CoA

Question 5

What type of drug would you administer for DVT?

Answer 5

Thrombolytic

Question 6

What antihypertensive would you give to a man with hypertension, microalbuminuria and T1DM diagnosed 10 years ago?

Answer 6

ACE inhibitor

Question 7

Man with Parkinson’s given L-DOPA and had nausea & vomiting. What drug would you give next ?

Answer 7

Carbidopa

Question 8

What is the MOA of fluoroquinolones?

Answer 8

inhibit topoisomerase IV

Question 9

Which anti-emetic could cause galactorrhea?

Answer 9

Metoclopramide (D2 receptor antagonist)

Question 10

What does atropine prevent during general anesthesia?

Answer 10

increased bronchial secretions

Question 11

Why does diazepam have a longer duration of action compared to other benzos?

Answer 11

it is broken down into active metabolites

Question 12

What is the role of GABA transaminase?

Answer 12

breaks down GABA to L-glutatmate

Question 13

A man is taking digoxin for AF, and presents to clinic with increased ventricular rate, what is the first biochemical test you should do?

Answer 13

K+

Question 14

first line treatment for alzheimers

Answer 14

anticholinesterase

Question 15

How does alcohol affect lipid and carbohydrate metabolism?

Answer 15

increases the NADH/NAD ratio

Question 16

What type of rxn is alcohol –> acetaldehyde?

Answer 16

oxidation

Question 17

Why is IV sodium bicarb given to treat aspirin overdose?

Answer 17

to increase urinary excretion of the drug by increasing plasma pH so drug is more ionised and excreted in kidneys

Question 18

What antihypertensive drug acts directly on the adrenal gland?

Answer 18

renin inhibitors

Question 19

Which antihypertensive should you not give to an asthmatic with hypertension?

Answer 19

beta blocker (block B2 mediated bronchodilation)

Question 20

What receptor does alcohol act on to cause euphoria?

Answer 20

opioid receptor inhibiting GABAergic neurons in VTA which increase DA release to NAcc –> eurphoria