Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BLOCK EXAM 2 > PHARM > Flashcards

PHARM Flashcards

1
Q

IF VD= 1 …

A

DRUG HAS WIDE DISTRIBUTION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

OPTIMUM DOSAGE REGIMEN SHOULD BE

A

ABOVE MINIMUM EFFECTIVE

BELOW MINIMUM TOXIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ALKALINIZATION OF URINE BY SODIUM BICARBONATE ENHANCES SECRETION OF

A

WEAK ACIDIC DRUGS SUCH AS ASPIRIN OR PHENOBARBITOL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

PROBLEMS WITH ACTIVE TUBULAR SECRETION

A

ACIDS COMPETE WITH ACIDS
BASES COMPETE WITH BASES
SATURATION CAN OCCUR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

FACTORS EFFECTING RENAL EXCRETION

A

LIVER DZ, KIDNEY DZ, AGE, URINE PH MODIFIERS, FLUID THERAPY, DIURETICS, PLASMA PROTEIN BINDING, DOSE, RATE OF ABSORPTION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

EXAMPLES OF DIURETICS

A

FUROSEMIDE

MANNITOL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

WHAT DRUGS REQUIRE ACTIVE TUBULAR SECRETION?

A

CHOLINE, DOPAMINE, NICOTINE, CIMETIDINE, PROCAINAMIDE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

GRAPEFRUIT JUICE IS AN

A

ENZYME INHIBITOR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

WHEN SHOULD YOU GIVE AN ENZYME INHIBITOR?

A

TO PREVENT LETHAL SYNTHESIS/ TOXICITY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

DISTRIBUTION AND STORAGE DISEASES ____ BIOTRANSFORMATION

A

DECREASE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

FLUID THERAPY AND DIURETICS WILL

A

INCREASE GLOMERULAR FILTRATION RATE

INCREASE EXCRETION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ACIDIFICATION OF URINE BY AMMONIUM CHLORIDE OR METHIONINE ENHANCES RENAL SECRETION OF

A

WEAK BASES

SUCH AS AMPHETAMINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

FACTORS ALTERRING BIOTRANSFORMATION

A 
SPECIES 
INDIVIDUAL 
ROUTE OF ADMINISTRATION
 ENZYME INDUCES 
ENZYME INHIBITORS 
LIVER DISEASE
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ACTIVE TUBULAR SECRETION REQUIRES _____. IT OCCURS IN THE ____.

A

ENERGY

PROXIMAL CONVOLUTED TUBULE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

WHAT ORGAN IS THE MAIN SITE OF BIOTRANSFORMATION?

A

LIVER

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

THERAPUETIC INDEX =

A

LD50/ ED50

LARGER VALUE =SAFER

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

IF VD >1 …

A

DRUG HAS VERY WIDE DISTRIBUTION

18
Q

TUBULAR REABSORPTION

A

WATER SOLUBLE, IONIZED POLAR DRUGS EXCRETED IN URINE

19
Q

FACTORS THAT EFFECT GLOMERULAR FILTRATION

A 
BLOOD FLOW 
CARDIAC OUTPUT 
BLOOD PRESSURE 
MOLECULAR SIZE (<7000 MAX. RATE) 
MOLECULAR CHARGE
20
Q

WHAT DRUGS ARE EXCRETED UNCHANGED IN THE URINE ?

A

QUATERNARY DRUGS

POLAR,IONIZED DRUGS

21
Q

NAME THREE DRUGS WITH AN EXTENSIVE EFFECT FROM FIRST PASS

A

LIDOCAINE
PROPANOLOL
MORPHINE

22
Q

SIGNIFICANT ENTEROHEPATIC CIRCULATION ____ THE HALF LIFE OF A DRUG

A

PROLONGS

23
Q

HERBIVORES HAVE ALKALINE URINE THEREFORE

A

WEAK ACID EXCRETED RAPIDLY

24
Q

IF VD <1 …

A

DRUG IS LIKELY TO STAY IN PLASMA

LIMITED DISTRIBUTION

25
Q

DRUGS SECRETED IN BILE

A

STEROID HORMONES, ERYTHROMYOCIN, NAICILLIN, DIGITOXIN, GLUCURONIDES OF CHLORAMPHENICOL, MORPHINE

26
Q

TMAX =

A

TIME TO REACH CMAX (MAX DRUG CONCENTRATION IN THE BLOOD).

27
Q

FLUORIQUINONE VD= 3.3
PENICILLIN VD= 0.2

WHICH HAS GREATER SYSTEMIC DIST?
WHICH HAS FASTER EXCRETION?

A

> SYSTEMIC CIRCULATION= FLUORIQUINONE

>EXCRETION= PENICILLIN

28
Q

CHARCOAL BROILED FOOD IS AN

A

ENZYME INDUCER

29
Q

IF YOU DECREASE ACTIVE TUBULAR SECRETION YOU ______ BIOTRANSFORMATION

A

DECREASE

30
Q

CMAX =

A

PEAK DRUG CONCENTRATION IN THE BLOOD

31
Q

F= SYSTEMIC BIOAVAILABILITY =

A

AREA UNDER CURVE EXTRAVASCULAR/ AREA UNDER CURVE IV *100

FRACTION OF DOSE THAT REACHES THE BLOOD INTACT

32
Q

CARNIVORES HAVE ACIDIC URINE THEREFORE

A

WEAK BASES EXCRETED RAPIDLY

33
Q

T1/2ALPHA IS THE ______ IN THE TWO COMPARTMENT MODEL

A

RATE OF DISTRIBUTION

34
Q

LARGE ANIMALS TEND TO BE MORE DRUG _________

A

TOLERANT

NEED HIGHER DOSES

35
Q

EXTRACTION RATIO

A

= (CONC. DRUG IN ARTERY/ CONC. DRUG IN VEIN )* CONC. DRUG IN ARTERY

36
Q

WHY DO WE GIVE ENZYMES INDUCERS

A

STIMULATE LIVER TO PRODUCE MORE METABOLIC ENZYMES

37
Q

IF YOU DECREASE TUBULAR REABSORPTION YOU ____ BIOTRANSFORMATION

A

INCREASE

38
Q

DRUGS THAT CANNOT BE METABOLIZED

A

HYDROPHOBIC, POLAR DRUGS

39
Q

CATS ARE DEFICIENT IN WHAT ENZYME

A

GLUCARONYL TRANSFERASE

40
Q

DEF OF COMPARTMENT

A

ANY REGION OF THE BODY WHERE THE RATE OF DRUG UPTAKE EQUALS THE RATE OF CLEARANCE

41
Q

IF YOU INCREASE GLOMERULAR FILTRATION YOU _____ EXCRETION

A

INCREASE

42
Q

ANIMALS IN THE TROPICS HAVE _____ BIOTRANSFORMATION

A

DECREASED

BLOCK EXAM 2 (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions