Pharm

Question 1

What types of receptors are specifically found in the vasculature of blood vessels?

Answer 1

A1
B2

Question 2

Where would you find B1 receptors? What do they induce?

Answer 2

Heart mainly, and kidney cells.
Chronotropic and Inotropic effects. ??
Increased myocardial contraction
Increased tachycardia

Question 3

What drug acts as a B1 receptor antagonist ?

Answer 3

Propranolol

Question 4

If propranolol acts as a B1 non selective antagonist what kind of effects does it have?

Answer 4

Decreased peripheral resistance
Decreased CO
Negative inotropic negative chronotropic effects

Used to treat hypertension

Question 5

What does propranolol block at the SA AND AV node?

Answer 5

NE

Question 6

Adverse reactions found with propranolol ?

Answer 6

Bronchi constriction

Question 7

Alpha 1 receptors are found in the vasculature. What type of effects would Epinephrine have on a1?

Answer 7

Vasoconstriction
Increased peripheral resistance

Question 8

What is a drug that acts as an a1 antagonist?

Answer 8

Prazosin

Question 9

Prazosin is a selective a1 antagonist. Mean it will do what to the sympathetic tone?

Answer 9

Decrease.
Cause a drop in resistance

Question 10

An adverse reaction of Prazosin is …

An favorable reaction of Prazosin is?

Answer 10

Orthostatic hypertension with first dose

Doesn’t effect CO

Question 11

What drug is used as an a2 receptor agonist?

Answer 11

Clonidine

Question 12

How does a2 receptors respond to Epi?

Answer 12

Decrease sympathetic tone

Question 13

Activation of a2 by Clonidine is used to treat what?

Answer 13

Hypertension
Withdrawals.

Question 14

When speaking of the receptors specifically found in the vasculature which one has a higher affinity for Epi?

Answer 14

B2.

Question 15

At low doses of epi what receptor is going to dominate?

Answer 15

B2.

Question 16

At high doses of epi what receptor will dominate ? Why?

Answer 16

A1, because there are more a1 found in the tissue than b1. But at a low dose b2 will dominate due to increased affinity for epi.

Question 17

What does b2 receptor cause when activated by epi or ne?

Answer 17

Vasodilation
Decreased resistance

Question 18

What are the sympathomimetic agonists we learned ?

Answer 18

Ep
NE
Clonidine

Question 19

Which drugs did we learn about that are considered beta blockers ?

Answer 19

Prazosin, a1 antagonist
Propranolol, b1 antagonist.

Question 20

What effect will NE have on an a1?

Answer 20

Increased BP»vagal response

Question 21

What metabolic factors stimulate coagulation ?

Answer 21

ADP
SEROTONIN
THROMBOXANE
Ca
platelet factors

Question 22

Rivaroxaban aka Xarelto is an oral agent used as a ………

Answer 22

Anticoagulant, Factor Xa inhibitor

Question 23

What is Xarelto used to treat ?

Answer 23

Prevents deep vein thrombosis following a hip or knee replacement

Question 24

Another anticoagulant we learned about us Abciximab aka ReoPro.
What receptor does it block

Answer 24

Glycoprotein IIB/IIA

Question 25

How does Abciximab ,ReoPro work

Answer 25

It’s a humanized mAb (hence the name) that binds to the GP IIB/IIA and prevents interaction with Fibrinogen and VWF

Prevents platelet aggregation

Question 26

An adverse effect of ReoPro is ?

Answer 26

Bleeding. It is an anticoagulant.