Pharm 5

Question 1

Of the sleep promoting medications/hypnotics, which one is known for a long 1/2 life and theoretically most risk of daytime sedation?

Answer 1

Eszopiclone (Lunesta) - t1/2 of nearly 6 hours.

Question 2

Riluzole is the only FDA approved medication for ALS…what is the MOA?

Answer 2

GLUTAMATE antagonist.

Question 3

Of the three GABA receptors GABA-A, GABA-B, and GABA-C, which one bind BZDS?

Answer 3

GABA-A (Chloride ion channel)

Question 4

What are the common SEs of Lithium?

Answer 4

1. Tremor
2. Nephrogenic Diabetes Insipidus (kidneys don’t respond to ADH)
3. Acne
4. Muscle weakness
5. Hypothyroidism
6. Weight gain
7. Edema
8. Leukocytosis
9. Psoriasis
10. Hair loss
11. Cardiac dysarrhythmias

Question 5

If a patient develops Lithium induced Diabetes Insipidus, what mediation combination might help and allow patient to stay on Lithium?

Answer 5

Amiloride + HCTZ

Question 6

What is the MOA of Mirtazapine?

Answer 6

Presynaptic Alpha-2 receptor blocker (stopping feedback inhibition of the release of NE, so increasing NE release)

Question 7

What are the three best BZDs for individuals with severe Liver disease ?

Answer 7

Temazepam
Oxazepam
Lorazepam

(These BZDs don’t take a “TOL” on the liver)

Question 8

What three SE of Fluoxetine set it apart from other SSRIs?

Answer 8

Headache
Respiratory complaint
Anxiety

Question 9

What medication can be helpful in treating TCA induced urinary retention?

Answer 9

Bethanechol

Question 10

If a patient develops akathisia on a neuroleptic and it doesn’t resolve with dose reduction…you can try switching to another agent….

What three neuroleptics have the least potential for Akathisia?

Answer 10

1. Seroquel
2. Olanzapine
3. Clozapine