Pharm 4

Question 1

What is the mechanism of action of Clonidine?

Answer 1

Pre-synaptic alpha 2 Agonist.

(Ultimately acts to inhibit release of NE from the presynaptic neuron, thus decreasing sympathetic tone in the body, decreasing arousal/activation)

Question 2

What is the mechanism of action by which antipsychotics cause orthostatic hypertension?

Answer 2

Alpha 1 adrenergic Antagonism.

Question 3

Sildenafil, Verdenafil and tadalafil all help Erective Dysfunction my what MOA?

Answer 3

Phosphodiesterase 5 Inhibitor.

PDE5 inhibition causes arterial smooth muscles to dilate allowing filling of cavernous of penis.

Question 4

What TCA also has DA blockade such that you should be concerned about EPS SE and even NMS?

Answer 4

Amoxapine.

Question 5

MAOIs can NEVER be given with what anesthetics bc of several deaths recorded in combination…what anesthetic is OK?

Answer 5

LIdocaine

Question 6

MOAI’s should never be concurrently administered with what OTC medications?

Answer 6

Any medications containing dextromethorphan (cold/flu med ingredient)

Question 7

What medications classically INCREASE Clozapine levels?

What medications classically DECREASE Clozapine levels?

Answer 7

INCREASE:

1) Cimetidine
2) SSRI
3) TCAs
4) VPA
5) Erythromycin

DECREASE:

1) Phenytoin
2) Carbamazepine

Question 8

Combination of Clozapine and Lithium can cause what negative effects?

Answer 8

• NMS
• Seizures
• Confusion
• Movement problems

Question 9

What is Ramelteon MOA?

WHERE in the brain does it act?

Answer 9

Melatonin receptor AGONIST

In the Suprachiasmatic nucleus of the hypothalamus

Question 10

After injection of Risperdal Consta, how long should you overlap with oral meds?

Answer 10

3-4 weeks.