Pharm 5

Question 1

pharmacokinetics

Answer 1

using volume of distribution and clearance determine

1. how often to dose a drug
2. what size dose to give
3. how long to expect a dose to last
4. when to re-dose a drug to sustain the effect

Question 2

steady state

Answer 2

4 X t1/2

Question 3

the does does not affect the time

Answer 3

to get to steady state

Question 4

2 X Cp at 1st t1/2 is

Answer 4

steady state conc.

Question 5

4 X t1/2 is about

Answer 5

93%

Question 6

define therapeutic index

Answer 6

Toxic dose / therapeutic dose

Question 7

alternative for therapeutic index

Answer 7

margin of safety = TD50 - ED50

Question 8

drug interactions can occur via

Answer 8

1. direct molecular
   - antibiotics and calcium
2. change absorption
   - charcoal binds drug molecules
3. protein binding and displacement