Pharm

Question 1

Triazalom

Answer 1

Short acting Benzo

Question 2

Insulin Rapid Acting

Answer 2

Glulsine
Lispart
Aspart

Toxicity: Hypoglycemia, sometimes hypersenstivity reaction

Question 3

Insulin short acting

Answer 3

Regular Insulin

Hyperkalemia (+gluose)
Stress hyperglycemia

Question 4

Insulin Intermediate acting

Answer 4

NPH

Question 5

Insulin Long acting

Answer 5

Glargine
Detemir

Basal glucose control

Question 6

Biguanide

Answer 6

Metformin

Toxicity: GI upset
- LACTIC ACIDOSIS (check RENAL)

Mech: Decrease gluconeogeneis, increase glycolysis, increase insulin sensitivy and peripheral uptake of glucose

Question 7

Sulfonylureas First Generation

Answer 7

Chlorporopamide
Tolbutamide

Can cause Disulfiram effects (shut down alco DH

CHECK RENAL FAILURE

Can’t use in TYPE 1

Close K+ channel on B cells, to Increase insulin release

Question 8

Sulfonylureas Second Generation

Answer 8

Glimepiride
Glipizide
Glyburide

Can cause HYPOGLYCEMIA

Check RENAL Failure

Question 9

Glitzaones/Thiazolidones

Answer 9

Pioglitazone
Rosiglitazone

Weight Gain, EDEMA
HEPATOTOXICITY, Check LFTs
HF
RIsk of Fractures

Increase insulin sensitivity through PPAR (perioxisome proliferator activated receptor (nuclear)

Question 10

GLP-1 Analogus

Answer 10

Exanatide
Liraglutide

Nausea, vomiting, pancreatitis

Increase insulin, decrease glucagon

Question 11

DPP-4 inhibitors

Answer 11

Linagliptin
Saxagliptin
Sitagliptin

Mild Urinary and Respiratory infections

Increase insulin, decrease glucagon

Question 12

Amylin Analog

Answer 12

pramlintide

Hypoglycemia, nausea, diarrhea

Decrease gastric emptying, decrease glucagon

Question 13

SGLT-2 Anaglog

Answer 13

Canagliflozin

Glucosruia, UTI, Vaginal/Yeast infections

Block reabsoprtion of glucose in renal tubule

Question 14

alpha-glucosidase inhibitor

Answer 14

Acarbose
Miglitol

GI disturbances

Inhibit intesintal brush border enzyme

Delayed carb hydrolysis and absorption

Question 15

Methimiazole

Answer 15

Block THYROID PEROXIDASE (inhibit oxidation of iodide and coupling of iodine

Skin Rash
AGRANULOCYTOSIS
Aplastic anemia
Teratogen (aplasia cutis)

Question 16

Propylthiouracil

Answer 16

Block Thyroid Peroxidase
Block 5-deiodinase in periphery to reduce changing of T4 to T3

Can be used in Preg

Skin rash
Agranulocytosis
Aplastic anemia
HEPATOTOXIC

Question 17

When do you use GH?

Answer 17

GH deficiency

TURNER SYNDROME

Question 18

When do you use oxytocin?

Answer 18

To induce labor
Uterine contractions
Milk let down
Control UTERINE HEMORRHAGE

Question 19

When do you use somatostatin?

Answer 19

Acromegaly

Carcinoid syndrome

Gastrinoma

GLucagonoma

Esophageal varices (reduce blood flow to varices)

Question 20

Demeclocycline

Answer 20

ADH Antagonist

Use in SIADH

Toxicity: Nephrogenic DI, Photosensitivity
Abnormalities of bone and teeth

Question 21

What are toxicities of glucocorticoids?

Answer 21

Mechanism: Inhibit phosopholipse A
Inhibit Tx factors such as NF-kB

Cushing syndrome
Hyperglycemia
Osteopororis
Amenorrhea
Immunosupression
Neutrophilia

Adrenal insufficiency if drug is stopped preemptively

Question 22

What is Cinacalcet?

Answer 22

Sensitizes Ca receptor in PT gland to circtulating Ca

Decreases amount of PTH

Use: Hypercalcemia due to primary or secondary hyperparathyroidism

Toxicity: Hypocalcemia