Neuro Pharm

Question 1

Butorphanol

Answer 1

K opioid agonist
Mu opioid partial agonist

Use in severe pain
Cause less resp depression

Toxicity: OPIOID withdrawal if used with real opioid

Question 2

Tramadl

Answer 2

Very weak opioid agonist
Inhibits 5-HT and NOREPI reuptake

use in Chornic pain

Toxicity: Decrease seizure threshhold
Serotonin syndrome (cognitive, autonomic, somatic)

Question 3

What antiseziure drugs can cause Steven johnson syndrome?

Answer 3

Ethosuximide
Phenytoin
Carabmazepine
Lamotrigine

Question 4

What blocks thalamic T-type Ca channels?

Answer 4

Ethosuximide

Question 5

What increases Gaba action by increasing frequency of Cl channel opening?

Answer 5

Benzos

First line in Status epilepticus and Eclampsia seisures (with MgSO4)

Question 6

What causes SLE like symptoms of the antiseizure drugs?

Answer 6

Phenytoin

Question 7

What toxicities does phenytoin have?

Answer 7

Nystagmus
Diplopia
Ataxia
Sedation
Gingival hyperplasia
Hirsuitism
Peripheral neuropathy
Megaloblastic anemia
TERATOGEN

SLE like syndrome

Induces p450

Lymphadenopathy
SJS
Osteopenia

Question 8

What is unique of carabmazepine toxicity?

Answer 8

Causes agranulocytosis, aplastic anemia

Liver toxicity (also valproic acid)

Question 9

What does topiramate cause?

Answer 9

Renal stones
Mental dulling
Sedation