pharm Flashcards
what pts are oral agents: insulin secretagogues (promotes secretion) / oral glucose lowering agents
pt c/ type II diabetes who cannot be managed by diet alone
T/F oral glucose should not be given to pts c/ type I Diabetes or because of progressive decline in Beta cells that occurs due to dz or aging
True
what is the MOA of sulfonylureas
promote insulin secretion from Beta cells of the pancreas
what oral hypoglycemic agent has a duration of action >24hrs
Pioglitazone (Actose)
what classes of oral agents are considered insulin secretagogues (promote secretion)
sulfonylureas , glinides
what classes are considered insulin sensitizers
Biguanides, thiazolidinediones
improve insulin action. lower BS by improving target cell response to insulin without inc pancreatic insulin sectretion
in type II diabetes what is a major source of/ accounts for the high BS on waking
excess glucose produced by the liver
what are some bonus- of taking metformin
can modestly reduce LDL, VLDL and inc HDL
when should you D/C metformin
if undergoing procedure requiring contrast
what does long term use of metformin interfere with
absorption of B12
is hyperinsulinemia a risk with glitazones
no, although insulin is required for their axn, these drugs do not promote insulin release from Beta cells
what 2 meds can cause ovulation to resume in premenopausal women with polycystic ovary syn
metformin and TZDs (thiazolidinediones) glitazones e.g. pioglitazone (Actos)
what drugs neither stimulate insulin release nor inc insulin action on target tissue
alpha glucosidase inhibitors e.g acarbose
what classes of oral agents improve insulin axn
biguanides and thiazolidinediones
which classes of glucose lowering agents have the ability to reduce insulin sensitivity
thiazolidinediones and biguanides
