Pharm

Question 1

Anthracycline

Answer 1

PRODUCE FREE RADICALS TO CLEAVE DNA AND CELL MEMBRANES Cardiotoxity

Question 1

Mitotic Inhibitors Taxanes

Answer 1

DISRUPTS MICROTUBULE FUNCTION

Question 1

Hormone Therapies

Answer 1

BIND TO CELL INHIBITING ACTIONS

Question 2

Immunotherapies (monoclonal antibodies)

Answer 2

TARGETS ANTIGENS EXPRESSED ON SURFACE OF CA CELLS. TARGETS TUMORAL ANGIOGENESIS, CUTTING OF BLOOD TO TUMOR.

Question 3

Corticosteroids

Answer 3

Not used as toxigenic, but for steroidal effects

Question 4

Topoisomerase Inhibitors

Answer 4

DNA STRAND BREAKS

Question 6

Antimetabolities

Answer 6

PREVENT DNA REPLICATION (Incorporated into R/DNA strand halting replication) Myelosuppression, nephro/hepatotoxicty

Question 7

Enzyme Inhibitors

Answer 7

INHIBIT ENZYMES NECESSARY FOR TUMOR PROLIFERATION

Question 8

Alkylating agents

Answer 8

PREVENT DNA REPLICATION (Add alkyl group to DNA preventing replication) Nephro/neuro/ototoxicty

Question 10

Gene Therpaies

Answer 10

ALTERATION OF GENES TO STOP DISEASE. OFTEN DONE USING VIRAL VECTOR TO ADD/REPLACE A GENE

Question 11

Immunotherapies (Biological response modifiers)

Answer 11

INCREASE BODY’S IMMUNE RESPONSE TO CA

Question 12

Antitubules

Answer 12

MESSES WITH MICROTUBULES Neurotoxicity

Question 13

Targeted therapies

Answer 13

SPECIFIC TO CERTAIN CA’s. BLOCK PROLIFERATION AND INDUCE APOPTOSIS

Question 14

Aromatase Inhibitor

Answer 14

STOPS PRODUCTION OF ESTROGEN IN POSTMENOPAUSAL WOMEN Osteoporosis, hot flashes