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Dermatology > Pharm > Flashcards

Pharm Flashcards

(59 cards)

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1
Q

Physical Sunscreens

A

Inorganics- titanium dioxide, zinc oxide

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2
Q

Chemical Sunscreens

A

cinoxate, para-aminobenzoic acid, trolamine, dioxybenzone, oxybenzone

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3
Q

Ustekinumab MOA

A

binds p40 subunit integral to IL12 and 23 activation. Tx psoriasis

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4
Q

AE of Ustekinumab

A

increased risk of infection and neoplasia, live virus vaccine contraindicated, test for TB before tx, anaphylaxis possible

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5
Q

BBW of infliximab

A

infection, neoplasia

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6
Q

Infliximab contraindications

A

heart failure, murine protein hypersensitivity

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7
Q

Etanercept contraindications

A

sepsis. BBW infections, neoplasia

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8
Q

Adalimumab BBW

A

infection, neoplasia

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9
Q

Target RAR

A

tretinoin, adapalene, tazarotene

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10
Q

Target RXR

A

bexarotene, alitretinoin

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11
Q

All oral retinoids are

A

potent teratogens

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12
Q

Calcipotriene MoA

A

topical, binds to Vit D receptor, RXRalpha - modulates epidermal differentiation and inflammation, improves psoriatic plaques

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13
Q

AE Calcipotriene

A

topical irritant, hypercalcemia, hypercalciuria, abdominal pain, constipation, depression, fatigue, HTN, anorexia, weight loss, muscle weakness, N/V, thirst, increased susceptibility to UV induced skin cancer

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14
Q

Benzoyl Peroxide

A

topical pro drug converted to benzoic acid in skin, free radicals kill nearby P. Acnes

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15
Q

AE Benzoyl Peroxide

A

dry skin, peeling, erythema, irritation, avoid mucous membrane contact, may bleach hair and clothing

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16
Q

Clindamycin MoA

A

Acne med. inhibits protein synthesis (50s). Lots of resistance within P. Acnes.

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17
Q

Basal Cell Tx

A

cisplatin, cyclophosphamide, doxorubicin, fluorouracil, MTX, vinblastine. Imiquimod, Vismodegib

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18
Q

SCC Tx

A

cisplatin

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19
Q

Melanom Tx

A

carmustine, dacarbazine, dactinomycin, docetaxel, lomustine, vinblastine. Aldesleukin, interferon, ipilimumab, sorafenib, trametinib, vemurafenib

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20
Q

Actinic keratosis Tx

A

fluorouracil, diclofenac, imiquimod, trichloroacetic acid

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21
Q

Imiquimod MoA

A

small molecule tumor directed immune response initiator, activates TLR7/8 and NFKB -> upreg of TNFalpha and interleukins. Prevents transcriptional upregulation of GL1

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22
Q

Imiquimod uses

A

BCC, Actinic keratosis, HPV

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23
Q

AE Imiquimod

A

allergies to benzyl alcohol and paraben components, skin rxns common (mild to mod), increased photosens, can compromise condoms and diaphragms

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24
Q

Aberrant SHH signaling implicated in

Study These Flashcards
A

Basal Cell Carcinoma. Leads to upreg of anti apop Bcl2, VEGF, angiopoietins. Pathway seems to be ligand independent, so must block at SMO or lower

25
Vismodegib MoA
oral SMO inhibitor, lipophilic with extensive metabolism
26
BBW of Vismodegib
fetal death, male teratogenecity, verify pt is not pregnant!
27
AE of Vismodegib
Alopecia, GI toxicity (N/V/D) common, weight loss, fatigue + BBW
28
Imiquimod is Category
C
29
Methotrexate is Category
X
30
Aldesleukin MoA
binds to cell surface IL2 receptor induces prolif and differentiation of B and T cells, monos, macros, CTLS and NK cells
31
Aldesleukin administered
IV or SC
32
BBW of Aldesleukin
contraindicated in pts with CNS, cardiac, pulmonary disease. Capillary leak syndrome
33
Aldesleukin contraindicated in
pts with CNS, cardiac, pulm, renal, hepatic disease or organ transplant
34
AE Aldesleukin
hypotension, s-tach, peripheral vasodilation, SVT, diminished mental status, speech diff, cortical blindness, limb or gait ataxia, hallucinations, agitation, dyspnea, pulm congestion, rales, rhonchi, renal failure caused by cap leak syndrome
35
Aldesleukin uses
Melanoma
36
Interferon alpha 2b administered
IV or SC
37
Interferon alpha 2b
Immunomodulator
38
Interferon alpha 2b BBW
caution in autoimmune disease, cardiac disease, depression
39
AE Interferon alpha 2b AE
caution in autoimmu, cardiac, depression, infection. Flu like rxn, neutropenia, leukopenia, anemia, alopecia, elevated LFTs, cough, dyspnea, pulm infiltrates, pneumonitis
40
Monitor in Interferon alpha 2b use
CBC, LFT, CXR
41
Ipilimumab MoA
CTLA-4 recomb antibody (cytotoxic t lympho assoc antigen 4) Bolsters antitumor response of immune system
42
Ipilimumab BBW
adrenal insuff, diarrhea, Guillan Barre, hepatitis, hyperthyroid, hypothyroid, myastenia gravis, per neuropathy, pregnancy, serious rash
43
Ipilimumab AE
dermatitis including TEN (toxic epidermal necrolysis), tiredness, diarrhea, itching, rash + BBW
44
Ipilimumab used for
melanoma tx
45
Sorafenib MoA and use
oral multikinase inhibitor (VEGF, PDGFR, KIT, Raf kinase) Tx melanoma
46
AE Sorafenib
elevated LFTs, peripheral neuropathy, rash/desquam, anemia, bone marrow supp, neutropenia, Cat D, increased bleeding in GI system, respiratory system, brain
47
Trametinib MoA
oral reversible MEK inhibitor
48
Trametinib used in pts with
BRAF V600E/K mutations
49
Trametinib AE
skin toxicity, dermatitis, erythema, hand-foot, diarrhea, stomatitis, anemia, decreased ejection fraction, HTN, hemorrhage, rare cardiomyopathy, interstitial lung disease, retinal pigment epithelial detachment
50
Vemurafenib MoA
oral inhibitor of mutated BRAF, genotype required for mutation evaluation
51
AE Vemurafenib
PGP and CYP interactions possible, elevated serum creatinine, QT prolongation, photosens, cutaneous SCC in 1/4 pts, SJS possible, uveitis, iritis, retinal vein occlusion
52
Monitor in Vemurafenib use
LFT, skin, ECG and electrolytes, eyes
53
Vemurafenib is Category
D
54
Sorafenib is Category
D
55
Trametinib is Category
D
56
Ald, ipi, and interferon A are category
C
57
MC AE in Vemurafenib
arthralgia, fatigue, rash, photosens, alopecia, N/D
58
Diclofenac
tx actinic keratosis, PGE2 inhibitor. AE: rash, itch, dry skin, peeling, redness
59
Trichloroacetic acid
tx actinic keratosis. chemical peel. AE: burning, inflammation, local tenderness

Dermatology (8 decks)

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