Pharm 2

Question 1

x

Answer 1

x

Question 2

x

Answer 2

x

Question 3

x

Answer 3

x

Question 4

x

Answer 4

x

Question 5

x

Answer 5

x

Question 6

x

Answer 6

x

Question 7

x

Answer 7

x

Question 8

Most drugs that undergo step 1 metabolism are deactivated by creation of a more soluble, less active compound. What are two notable exceptions where action of P450 activates a drug?

Answer 8

Codeine—>morphine

Hydocodone–>hydromorphone

Question 9

Most drugs that undergo step 1 metabolism are deactivated by creation of a more soluble, less active compound. What is one notable exception where action of P450 creates a toxic metabolite?

Answer 9

acetaminophen—>N-Acetyl-benzoquinoneimine (hepatotoxic)

Question 10

Most drugs that undergo step 1 metabolism are deactivated by creation of a more soluble, less active compound. What are three notable exceptions where action of P450 activates a prodrug?

Answer 10

Omeprazole  a sulfenamide
Enalapril  Enalaprilat
Valacyclovir  Acyclovir

Question 11

1 oz (weight)

Answer 11

28.35 grams (often see 30 grams used)

Question 12

1 drop

Answer 12

0.05 ml

Question 13

1t

Answer 13

5ml

Question 14

1T

Answer 14

15mL

Question 15

1oz (volume)

Answer 15

29.56 ml (often see 30 ml used) 30 mL

Question 16

LD

Answer 16

loading dose

Question 17

MD

Answer 17

maintenance dose

Question 18

F

Answer 18

bioavailability. Used to convert from oral to IV and vice-versa

Question 19

Vd

Answer 19

Volume of distribution. Used to convert dosage to plasma concentration.

Question 20

Half-life [t1/2] allows quick rule-of-thumb estimates of:

Answer 20

1) Time for elimination of drug from plasma (4-5 half-lives)2) Time to reach steady state plasma drug levels following multiple doses (4-5 half-lives) 3) Fluctuations in plasma levels between doses (number of half-lives in dosing interval)

Question 21

Rate of absorption is _____ from bioavailability.

Answer 21

independent