Inhibitors/Inducers Flashcards
1
Q
Inducers Phenobarbital [1A2, 2C8, 3A4] Phenytoin [2C9, 3A4] Carbamazepine [2C9, 3A4] Rifampin [1A2, 2C9, 2C18, 3A4] Ethanol [2E1] St. John’s Wort [3A4] Tobacco / marijuana smoke (not nicotine) [1A2]
Inhibitors Cimetidine [2D6, 3A4, 1A2] Erythromycin / Clarithromycin [1A2, 3A4] Antifungal agents (Ketoconazole [3A4], Itraconazole) Omeprazole [2C19] Grapefruit juice [3A4] Fluoxetine (and other SSRIs) [2D6, 3A4]
A
x
2
Q
Phenobarbital
A
3A4 inducer
3
Q
Phenytoin
A
3A4 inducer
4
Q
Carbamazepine
A
3A4 inducer
5
Q
Ethanol
A
2E1 inducer
6
Q
St. John’s Wort
A
3A4 inducer
7
Q
Tobacco/marijuana smoke (not nicotine)
A
1A2 inducer
8
Q
Cimetidine
A
2D6, 3A4 inhibitor
9
Q
Erythromycin / Clarithromycin
A
3A4 inhibitor
10
Q
Antifungal agents (Ketoconazole, Itraconazole)
A
3A4 inhibitor
11
Q
Omeprazole
A
2C19 inhibitor
12
Q
Grapefruit juice
A
3A4 inhibitor
13
Q
Fluoxetine (and other SSRIs)
A
2D6, 3A4 inhibitor
14
Q
3A4 inhibitors
A
A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls
Acute alcohol abuse Gemfibrozil Ciprofloxacin Isoniazid Grapefruit juice Quinidine Amiodarone Ketoconazole Macrolides Sulfonamides Cimetidine Ritonavir
15
Q
3A4 inducers
A
Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs
Chronic alcohol use Modafinil St. John’s wort Phenytoin Phenobarbital Nevirapine Rifampin Griseofulvin Carbamazepine
