Inhibitors/Inducers

Question 1

Inducers
Phenobarbital [1A2, 2C8, 3A4]
Phenytoin [2C9, 3A4]
Carbamazepine [2C9, 3A4]
Rifampin [1A2, 2C9, 2C18, 3A4]
Ethanol [2E1]
St. John’s Wort [3A4]
Tobacco / marijuana smoke (not nicotine) [1A2]

Inhibitors
Cimetidine [2D6, 3A4, 1A2]
Erythromycin / Clarithromycin [1A2, 3A4] Antifungal agents (Ketoconazole [3A4], Itraconazole) Omeprazole [2C19]
Grapefruit juice [3A4]
Fluoxetine (and other SSRIs) [2D6, 3A4]

Answer 1

x

Question 2

Phenobarbital

Answer 2

3A4 inducer

Question 3

Phenytoin

Answer 3

3A4 inducer

Question 4

Carbamazepine

Answer 4

3A4 inducer

Question 5

Ethanol

Answer 5

2E1 inducer

Question 6

St. John’s Wort

Answer 6

3A4 inducer

Question 7

Tobacco/marijuana smoke (not nicotine)

Answer 7

1A2 inducer

Question 8

Cimetidine

Answer 8

2D6, 3A4 inhibitor

Question 9

Erythromycin / Clarithromycin

Answer 9

3A4 inhibitor

Question 10

Antifungal agents (Ketoconazole, Itraconazole)

Answer 10

3A4 inhibitor

Question 11

Omeprazole

Answer 11

2C19 inhibitor

Question 12

Grapefruit juice

Answer 12

3A4 inhibitor

Question 13

Fluoxetine (and other SSRIs)

Answer 13

2D6, 3A4 inhibitor

Question 14

3A4 inhibitors

Answer 14

A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls

Acute alcohol abuse 
Gemfibrozil 
Ciprofloxacin 
Isoniazid 
Grapefruit juice 
Quinidine 
Amiodarone 
Ketoconazole 
Macrolides 
Sulfonamides 
Cimetidine 
Ritonavir

Question 15

3A4 inducers

Answer 15

Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs

Chronic alcohol use 
Modafinil
St. John’s wort 
Phenytoin 
Phenobarbital 
Nevirapine 
Rifampin 
Griseofulvin 
Carbamazepine

Question 16

Azole antifungals

Answer 16

Inhibitor

Question 17

HIV protease inhibitors

Answer 17

Inhibitor

Question 18

Rifampin (also what common medication does this affect?)

Answer 18

Inducer. Increases clearance of oral contraceptive. May lead to unintended pregnancy.