Pharm 2

Question 1

What drugs and conditions reduce psueodcholinesterase activity?

Answer 1

Question 2

How do you treat kyperkalemia from succinylcholine?

Answer 2

Question 3

What patients are at risk of developing hyperkalemia following succinylcholine?

Answer 3

Question 4

How are the benzylisoquinoliniums metabolized?

Answer 4

spontaneous degradation in the plasma
Atracurium: plasma esterases
Cis: hoffman
Mivicurium: pseudocholinesterase

Question 5

How are the aminosteroid NMBs metabolized and eliminated?

Answer 5

Question 6

What drugs can potentiate the effects of NMB’s?

Answer 6

Question 7

What electrolyte disturbances can potentiate NMB’s?

Answer 7

increased: lithium and magnesium
decreased: calcium and potassium

Question 8

What are the three ways to inhibit AchE?

Answer 8

Electrostatic attachment - edrophonium
Carbamyl esters - neostigmine, pyridostigmine, physostigmine
Phosphorylation- organophosphate and echothiophate

Question 9

What is the dose, onset, DOA, metabolism, and pairing of endrophonium?

Answer 9

Question 10

What are s/sx of serotonin syndrome?

Answer 10

hyperthermia, mental status changes, hyperreflexia, seizures, death