Pharm

Question 0

Atropine and pralidoxime are antidotes for what?

Answer 0

Acetylcholinesterase inhibitors and organophosphates

Question 1

Antidote for Amphetamines ?

Answer 1

NH4Cl, acid files urine

Question 2

Antidote for antimuscarinic and anticholinergic agents

Answer 2

Physostigmine salicylate, controls hyperthermia

Question 3

Antidote for beta-blockers? What is beta blocker used as antidote for?

Answer 3

Beta blocker toxicity: Glucagon

Beta blockers used as antidote for Theophylline

Question 4

Overdose on digitalis. What can you take?

Answer 4

Tx w/ KLAM

Normalize K+, Lidocaine, Anti-dig Fab fragments, Mg

Question 5

Iron overload, use..

Answer 5

Deferoxamine, deferasirox

Question 6

Lead toxicity treatment?

Answer 6

CaEDTA, dimercaprol, succimer, pencillamine

Question 7

Antidote use of penicillamine used for?

Answer 7

Toxicity by Copper, arsenic, gold, and Lead

Question 8

Amino parodic acid used to treat what toxicity?

Answer 8

Streptokinase, urokinase, and tPA

Question 9

Heparin overdose. Give?

Answer 9

Protamine

Question 10

Mercury toxicity antidote. What else is Antidote used for?

Answer 10

Antidote: dimercaprol (BAL), succimer

Also used for arsenic and gold toxicity

Question 11

Cyanide toxicity Tx

Answer 11

Nitrite & thiosulfate, hydroxycobalamin

Question 12

Methemoglobin toxicity antidote

Answer 12

Methylene blue, Vit. C

Question 13

Give patient 100% O2 or hyperbaric O2 for what toxicity

Answer 13

Carbon monoxide

Question 14

Methanol toxicity antidote?

Answer 14

Dialysis, fomepizole > EtOH

Question 15

Dumbass kid drinks anti-freeze. You tell parents, “you two are retarded. We can take of this and give your dumbass kid —- for antidote?” What do you give?

Answer 15

Dialysis, fomepizole > EtOH

Question 16

Naloxone and naltrexone are antidotes for?

Explain Naloxone effects

Answer 16

Opioids

Naloxone effect: reverses analgesia, sedation, hypotension. Respiratory depression. Works in minutes!

Question 17

Benzodiazepine overdose. Give?

Answer 17

Flumazenil

Question 18

TCAs overdose. Antidote?

Answer 18

NaHCO3 (plasma alkalinization)

Question 20

Tx for Narcolepsy

Answer 20

Daytime stimulants (amphetamine, modafinil)

Nighttime Sodium (GHB)

Question 21

Tx for Cystathione synthase deficiency

Answer 21

Decrease Methionine

Increase Cysteine, B12, & folate (diet)

Question 22

Tx for Type II, Crigler Najjar syndrome

Answer 22

Phenobarbital, which increases liver enzymes

Question 23

Wilson’s disease Tx?

Answer 23

Penicillamine

Question 24

Hemochromatosis Tx?

Answer 24

repeated phlebotomy
Deferasirox
Deferoxamine

Question 25

What inhibits thymidine synthase? Effect?

Answer 25

5-Fluorouracil (5-FU)

The enzyme causes uracil to become thymidine (dUMP–> dTMP). Lack of dTMP (needed for DNA replication) leads to death of cancer cells.