Pharm #10 - Chronic CHF Flashcards
1
Q
What drugs treat chronic CHF?
A
- DIgoxin
- Diuretics
- ACE inhibitors
- ATReceptor blockers
- B- adrenergic blocking agents
2
Q
Which diuretics prevent ventricular remodeling and fibrosis?
A
Spironolactone and eplerenone
3
Q
ATII receptor blockers Clinical effect - 3
- losartan
- valsartan
- irbesartan
- candesartan
- LCZ696
A
Reduces preload by causing vacillation of venous capacitance vessels
- reduces afterload
- prevent ventricular remodeling
Use for CHRONIC CHF especially patients intolerant to ACE inhibitors
4
Q
Which 3 b blockers are used for CHRONIC CHF?
A
- carvedilol
- metoprolol
- bucindolol
5
Q
Clinical use of B - blockers for chronic CHF
A
- decrease HR
- decreased myocardial damage due to chronic sympathetic stimulation
- prevent LV remodeling
6
Q
Contraindications of B blockers
A
Acute exacerbations of chronic CHF
- asthma
- COPD
- insulin dependent diabetes mellitus
7
Q
What drug increases mortality in patients with chronic CHF by increasing frequency of arrhythmias?
A
Oral agent –> milrinone (phosphodiesterase inhibitor)
