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Musculoskeletal System > Pharm 1 and 2 > Flashcards

Pharm 1 and 2 Flashcards

1
Q

Erectile dysfunction, drug and its effect

A

PGE1, vasodilator

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2
Q

Glaucoma, drug and its effect

A

PGE1, PGE2 eye drops, vasodilation opening the canal of schlem

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3
Q

Ductus arteriosus

A

There are situations where you want this to be open

Open- vasodilator, Close- vasocontrictor

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4
Q

Labor and Abortion, drugs and there effects

A

PGF2alpha– SM contraction, abortion

PGE2–dilates the opening of the uterus

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5
Q

Pulmonary Hypertension, drug and its effect

A

PGI2- vasodilator

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6
Q

secreted exclusively by endothelial cells, vasodilation, relief of symptoms

A

PGI2

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7
Q

constitutive (housekeeping)– produces prostacyclin (relaxing smooth muscles of vessels, blood flow easily)

A

COX1

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8
Q

inducible by inflammatory responses (indicative of pathologic)

A

COX2

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9
Q

high vasoconstrictor–> prone for ischemic events

A

PGF2alpa and PGD2

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10
Q

Treatment of arthritis

A

block COX2 and administer PGE2

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11
Q

Arthritis (rheumatoid, osteoarthritis etc)

A

COX2 and PGE2 are marked

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12
Q

PGE2

A

eicosanoid, central to rheumatoid and osteo arthritis, potent vasodilator (good, same as PGE1) , causes pain (bad thing, lowers the threshold of pain)

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13
Q

Asthma, general treatment

A

Both PGD2 and LT
LTC4 & LTD4
- Block LT synthesis

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14
Q

Crohn’s disease and Ulcerative colitis

A

Increased LTB4 in the affected mucosa causes an increase in leukocyte infiltration

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15
Q

Evidential relationship between eicosanoids and cancer

A

chronic asthma medication and low colon cancer

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16
Q

CV disease

A

PGE2 and PGE1 and PGI– vasodilators

17
Q

Prostacyclins

A

produced by endothelial cells lining the blood vessels

18
Q

Thromboxanes are synthesized by

A

synthesized by platelets

19
Q

Dysmenorrhea

A

Endometrium  PGE2 and PGF2

PGF2

20
Q

PGF2alpha

A

constrictor of SM, uterine contractions to abort the fetus

21
Q

PGE2

A

dilation of the uterus

22
Q

Glomerulonephritis

A

Abnormal elevation of LTB4 due to complement proteins

Cysteinyl leukotrienes   glomerular filtration

Musculoskeletal System (9 decks)

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