Pharm 1

Question 1

Epithelial cells

Answer 1

make up the overall lining of the stomach

Question 2

mucous neck cells

Answer 2

secrete mucous to serve as a protective barrier between the acid and the epithelial cells

Question 3

Regenerative cells

Answer 3

replace damaged epithelial cells

Question 4

Parietal cells

Answer 4

Secrete acid

Question 5

Chief cells

Answer 5

secrete pepsinogen

Question 6

Endocrine cells

Answer 6

secrete factors that communicate with more distant cells in the body via the bloodstream

Question 7

Two most common medication therapy targets

Answer 7

Proton, or acid, pumps

Histamine receptors

Question 8

Stimulants of acid secretion

Answer 8

Acetylcholine (ACh)
Histamine
Gastrin

Question 9

Inhibitors of acid secretion

Answer 9

Somatostatin

Prostaglandins

Question 10

ECL cell

Answer 10

responsible for histamine release

Question 11

D cell

Answer 11

Somatostatin release

Question 12

G cell

Answer 12

gastrin release

Question 13

Regulation of acid secretion

Answer 13

ACh –> ECL cell –> histamine –> stimulates acid secretion along with stimulating the parietal cell directly to secrete acid
ACh –> delta cell –> prevent release of somatostatin –> increases release of gastric acid
ACh –> GRP (gastrin releasing peptide) –> gastrin into the bloodstream and stimulates acid secretion by the parietal cell
Gastrin –> D cells –> somatostatin (negative feedback)
Mucosa then decreases the release of gastrin and directly decreases gastric acid secretion at the parietal cell