PH2107 - Oral Suspensions & liquids Flashcards

1
Q

Which patients may need to be prescribed an oral liquid medicine?

A

Patients who are unable to swallow oral solids easily
Patients who require a dose which is difficult to deliver accurately through available solid oral dosage forms
Also in certain patients / conditions where a faster onset of action is required vs. solid oral form

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2
Q

What are the disadvantages to using oral liquid medicines?

A

Cost is usually higher

Less stable

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3
Q

Why might patients have difficulty in swallowing?

A
  • psychological aversion
  • age (old and young)
  • dysphagia
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4
Q

What factors do pharmacists need to be aware of when supplying medicines to children?

A
  • age, development level etc. can all factor into decision over what is best dosage form
  • yet a study showed 35% of parents/guardians didn’t feel involved in decisions about their child’s care or treatment
  • younger children more likely to have medicines administered by their parent/guardian while older children more likely to take responsibility for their own medication
  • younger children are likely to focus on taste mainly
  • older children may be more sensitive to stigma of taking medication e.g. at school and may prefer more transportable forms
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5
Q

What factors do pharmacists need to be aware of when supplying medicines to elderly patients?

A
  • reduction of saliva production / weakening of muscles involved in swallowing
  • estimates from 60 - 90% of elderly have some degree of difficulty swallowing solid dosage forms
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6
Q

What two types of dysphagia can patients suffer from?

A
  • acute e.g. sore throat

- longer term e.g. stroke, Parkinson’s, muscular dystrophy, oesophageal cancer

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7
Q

How many patients suffer from dysphagia?

A

Studies suggest that dysphagia has been found to affect up to:

  • 15% of residents in general care homes for older people
  • 30% patients in hospices
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8
Q

What factors in taking medicine are important to patients?

A
  • ease of dosing
  • palatability
  • acceptability of excipients
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9
Q

What factors need to be considered with ease of dosing?

A
Frequency
- usually not unique to oral liquid formulations as patients prefer less frequent doses
Volume
- amount needed to be taken at a time
- large volumes mean taste more relevant
- volume per bottle - convenience - large doses need large bottles which are hard to carry around
Administration
- how is it measured and administered
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10
Q

What is palatability?

A

The overall appreciation of a medicinal product in relation to its smell, taste, aftertaste and texture (i.e. feeling in the mouth)

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11
Q

What is a key factor affecting acceptability of oral medication by children and the elderly

A

Palatability

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12
Q

What flavour medication do children prefer?

A

Fruit flavours - strawberry or banana
Cola
Chocolate

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13
Q

What flavour medication do older patients prefer?

A

Loss of taste with age so prefer stronger flavours e.g. mint

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14
Q

What flavour do patients expect GI medicines to be?

A

Mint or aniseed flavoured

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15
Q

Why is colour an important consideration in medicines?

A

Psychological impact of colours

Expectations - e.g. never see blue liquid medicines - doesn’t feel right

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16
Q

What three excipients are often added to medicines?

A
  • sugar
  • alcohol
  • colourants
17
Q

Why is sugar often added to medicines?

A

To increase palatability

18
Q

Why are sugar free medicines often preferred?

A

Negative health impacts of sugar becoming increasingly important to patients

19
Q

What effect can sugar free preparations have?

A

Laxative effect e.g. sorbitol

20
Q

What problems do colourants have in medications?

A

Link to hyperactivity in some children

21
Q

Which three points should storage of oral liquid medicines be considered?

A

Manufacture to wholesale
In the pharmacy before it is dispensed
At the patient’s home

22
Q

Why is “Keep out of the sight and reach of children” important?

A

Of particular importance in the patient’s home

- oral liquids can be tempting to children (flavour)

23
Q

How can children be protected from dangerous medicines?

A

Keep out of the sight and reach of children warning label
Child-resistant closure
Keep medicines in an inaccessible place

24
Q

Why is the expiry date of a medication important?

A

Depends on individual product (e.g. freshly/recently prepared)
Shorter use by date (than expiry date) if reconstituted

25
Q

What things need to be considered when dispensing an oral liquid medication?

A
Quantities to prescribe / dispense
- original pack size?
- reconstitution?
Labelling
Spoons/syringes
Different strength
26
Q

How much medicine should be supplied?

A

You should supply a manufacturer’s original pack wherever possible BUT if a prescriber orders a quantity that does not match an original then you will need to measure out the correct amount, unless it is in a “special container”

27
Q

What should measured volumes of oral liquid medicines be dispensed in?

A

A suitable container with a child-resistant closure

28
Q

What needs to be done to a suspension before measuring it out?

A

The bottle needs to be shaken

29
Q

What volume of reconstituted antibiotics should be dispensed?

A

If amount prescribed doesn’t match the pack size, then you should round UP
- e.g. if 140ml ordered, but pack size is 100ml, then reconstitute and supply 2 x 100 ml bottles
- warn patient that excess has been dispensed
If course / amount prescribed exceeds the expiry date once reconstituted, you’ll need to provide part supply and patient will need to return for the remainder

30
Q

How will the patient measure the medication accurately so they get the correct dose?

A

Provide the appropriate means and, where possible, refer to this on the label i.e. using the oral syringe provided give . . .

31
Q

How might a patient know if they are taking a different strength of a tablet?

A

If it usually a different size or colour

32
Q

Why might patients take a different dose to that expected with an oral liquid medication?

A

Liquid medications (especially unlicensed ones) are less obvious if they are different strengths. Patients may take the same volume as usual, but end up with a very different dose

33
Q

How can problems with dosing oral liquid medications be avoided?

A

Be sure to communicate clearly if you are dispensing a different strength preparation from what the patient has had in the past

34
Q

Who should you counsel when dispensing oral liquid medications?

A

Wherever possible, you should counsel the person who will be administering the medication
- in most cases this is the patient themselves

35
Q

should a pharmacist counsel a child when dispensing oral liquid medications?

A
  • communicating with children about their medications can significantly impact on their willingness to take, and adherence to, their medication
  • consider discussing medicines with children as well as their parent/guardian
  • GPhC requires pharmacists to communicate effectively
  • tailoring and adapting your communication to ensure the patient understands - consider this carefully when communicating with children in particular
36
Q

What are the most important administration points to cover?

A

The usual counselling points (e.g. dose frequency)
Instructions on storage
Need to shake the bottle before administration (where appropriate)
How to measure the dose correctly

37
Q

As patients can only remember a limited amount of information at one time, how can information be delivered?

A

Highlight other sources of information

  • label
  • PIL
38
Q

Describe the disperse phase in an emulsion

A