pH, pKa, Buffers Flashcards
What makes up extent of dissociation
amount of protons released vs total amount of compound
Strength of acid
Every factor of 10 differenc in [H+] is?
1.0 pH unit
Every factor of 2 difference in [H+] is?
0.3 pH unit
What does titration do?
Describes ratio of conjugate base and acid
if pH is equal to pKa, how does this correlate to concentrations?
concentrations are equal
pH greater than pKa, correlates to concentrations how?
conjugate base concentration is greater than acid concentration
pH is less than pKa, correlats to concentrations how?
conjugate base concentration less than acid concentration
normal blood pH
7.40 +/- 0.05
normal blood CO2
1.20 mM
normal blood PCO2
40 mmHg
normal blood [HCO3-]
24 mM
blood pH less than 7.35 is?
Acidosis
blood pH greater than 7.45 is?
Alkalosis
Respiratory acidosis
Decrease ventilation, increased PCO2, (over 40mmHg), HCO3- greater than 24mM, partial renal compensation
Metabolic acidosis
decreased extracellular fluid HCO3- under 24mM, PCO2 under 40mmHg, partial respiratory compensation