PFTs Flashcards

1
Q

When is a PFT indicated?

A

anyone presenting with dyspnea, SOB, cough, pre-operative evaluation, disability

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2
Q

How is spirometry performed?

A

patient is sitting and after tidal volume, max inspiration and max expiration are performed 3 times and then average is taken

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3
Q

What is functional residual capacity?

A

volume of air left after normal expiration (obese decreases this)

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4
Q

Slow expiration is key in spirometry evaluation of which patients?

A

those with obstructive disease

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5
Q

Pulmonary function peaks at what age?

A

25 (secular trend of decline- 25-30cc decline/year)

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6
Q

T or F. The initial part of expiration is EFFORT dependent

A

T. The terminal portion is not and is driven by elastic recoil of the lung

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7
Q

When is a post-bronchodilator response considered positive?

A

An increase of at least 200ml (AND 12%) in FEV1 or 15% from basal FEV1

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8
Q

What is an MVV?

A

Maximal volume ventilation= max inhale and exhale as many times as possible in 12 seconds (needed before lung resection)

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9
Q

What is a normal MVV?

A

40x FEV1

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10
Q

What MVV is needed for pneumonectomy?

A

greater than 55%

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11
Q

What MVV is needed for lobeectomy?

A

greater than 45%

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12
Q

A low MVV suggests what?

A

muscle fatigue

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13
Q

What part of lung function can not be measured with spirometry?

A

residual volume

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14
Q

What lung parameter is very important int he evaluation of hypoxemia in the ICU?

A

FVC

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15
Q

FEV1/FVC is reduced in what type of disease?

A

obstructive ONLY

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16
Q

FVC is reduced in obstructive or restrictive?

17
Q

FEV1 is reduced in obstructive or restrictive?

18
Q

What things reduce TLC?

A
  • disease of the thorax or inspiratory muscles
  • pleural diseases
  • loss of alveoli
19
Q

What things reduce VC?

A
  • chest pain

- fatigue or poor effort

20
Q

Why does dynamic hyperinflation occur in obstructive disease?

A

Not being able to get out all the air causes “stacking”

21
Q

In restrictive diseases, compliance is decreased

A

T. Harder to inhale, easier to exhale

22
Q

How does compliance change in asthma patients?

A

it doesn’t even though its obstructive (no destruction of tissue) BUT FEV1/FVC still decreases

23
Q

How does compliance change in emphysema patients?

24
Q

Flow velocities during exhalation are higher in which type of lung disease?

A

restrictive

25
Flow volume loops are also used to evaluate what?
upper-airway obstruction (carina and up)
26
What is the difference between extra-thoracic and intra-thoracic?
extra- suprasternal notch up intra-carina up to suprasternal notch
27
What part of the flow-volume loop is flattened in extra-thoracic disease?
inhalation
28
What part of the flow-volume loop is flattened in intra-thoracic disease?
exhalation
29
What is a fixed Upper airway obstruction?
where you see flattening of both the inspiratory and expiratory portions of the flow-volume curve
30
What is lung diffusion capacity defined as?
rate at which gas enters the blood divided by the driving pressure of the gas (PA-Pa)
31
How is DLCO measured?
SINGLE breath (requires inhaled VC of greater than 1 L and 10 of breath holding)
32
Interpreting DLCO
Change is DLCO 7% per gram of Hb
33
What is a normal DLCO?
81-140% | 76-80%- borderline
34
What things can increase DLCO?
putting blood/Hb in the lungs (e.g. CHF, pulmonary hemorrhage)
35
What are the uses of DLCO?
- differentiate between asthma and COPD, or interstitial and chest wall disease - diagnose pulmonary vascular disease
36
What things would show normal PFT and low DLCO?
pulmonary emboli or HTN
37
A negative methacholine challenge rules out ____
asthma (more than 20+% decrease with less than 1mg/ml methacholine in FEV1= hypersensitivity)