Peutz-Jeghers syndrome

Question 1

Genetics

Answer 1

autosomal dominant

Question 2

Clinical features

Answer 2

hamartomatous polyps in GI tract (mainly small bowel)

pigmented lesions on lips, oral mucosa, face, palms and soles

intestinal obstruction e.g. intussusception

gastrointestinal bleeding

Question 3

Management

Answer 3

conservative unless complications develop

Test for complications: cancer screening