Gilbert's Syndrome

Question 1

What is Gilbert’s Syndrome?

Answer 1

Gilbert’s syndrome is an autosomal recessive* condition of defective bilirubin conjugation

due to a deficiency of UDP glucuronosyltransferase.

Question 2

Clinical Features of Gilbert’s Syndrome

Answer 2

Isolated Unconjugated hyperbilirubinaemia (i.e. not in urine)

Jaundice may only be seen during an intercurrent illness, exercise or fasting

Question 3

Diagnosis of Gilbert’s Syndrome

Answer 3

Rise in bilirubin following prolonged fasting or IV nicotinic acid

Question 4

Management

Answer 4

No treatment - reassure and discharge